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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

mut-7  -  Protein MUT-7

Caenorhabditis elegans

 
 
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High impact information on mut-7

  • We now report that mutants of C. elegans that are defective in transposon silencing and RNA interference (mut-2, mut-7, mut-8 and mut-9) are in addition resistant to co-suppression [1].
  • In contrast, the rde-2 and mut-7 genes were required downstream for interference [2].
  • The High chlorophyll fluorescence106 (Hcf106) gene in maize is required for chloroplast membrane biogenesis, and the hcf106-mum1 allele is caused by the insertion of a Robertson's Mutator Mu1 element into the promoter of the gene [3].
  • To do this, we analyzed the distribution of recent mutant insertions of the Tc1, Tc3, and Tc5 elements in a mut-7 background of the nematode Caenorhabditis elegans and compared it to the distribution of element insertions (presumably fixed) within the sequenced genome [4].
  • When a germline-expressed reporter gene is fused to a stretch of Tc1 sequence, this transgene is silenced in a manner dependent on functional mutator genes (mut-7, mut-16 and pk732) [5].

References

  1. A genetic link between co-suppression and RNA interference in C. elegans. Ketting, R.F., Plasterk, R.H. Nature (2000) [Pubmed]
  2. Genetic requirements for inheritance of RNAi in C. elegans. Grishok, A., Tabara, H., Mello, C.C. Science (2000) [Pubmed]
  3. Site-selected transposon mutagenesis at the hcf106 locus in maize. Das, L., Martienssen, R. Plant Cell (1995) [Pubmed]
  4. Patterns of selection against transposons inferred from the distribution of Tc1, Tc3 and Tc5 insertions in the mut-7 line of the nematode Caenorhabditis elegans. Rizzon, C., Martin, E., Marais, G., Duret, L., Ségalat, L., Biémont, C. Genetics (2003) [Pubmed]
  5. Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi. Sijen, T., Plasterk, R.H. Nature (2003) [Pubmed]
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