Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

daf-1 - Protein DAF-1

Caenorhabditis elegans

Georgi, L.L. et al., Lin, H.Y. et al., Inoue, T. et al., Joshua, G.W. et al., Krishna, S. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on daf-1

A daf-1 probe detects a 2.5 kb mRNA of low abundance, and the DNA sequence indicates that the gene encodes a 669 amino acid protein, with a putative transmembrane domain and a C-terminal protein kinase domain most closely related to the cytosolic, raf proto-oncogene family [1].
To identify additional genes that function in this pathway, we carried out a screen for suppressors of mutations in daf-1, daf-8, and daf-14 [2].
These mutants, srf-2, srf-3, srf-5 and the dauer pathway gene daf-1, also exhibit altered binding of lectins to the nematode surface [3].
The cloned type II receptor has a predicted protein core of about 60 kDa with a cysteine-rich extracellular domain, a single transmembrane domain, and a functional serine/threonine kinase domain that is homologous to the activin receptor and to the C. elegans protein daf-1 [4].

Analytical, diagnostic and therapeutic context of daf-1

In addition, it is also required for body size determination and male tail patterning, roles which do not require daf-1 [5].

References

daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase. Georgi, L.L., Albert, P.S., Riddle, D.L. Cell (1990) [Pubmed]
Suppressors of transforming growth factor-beta pathway mutants in the Caenorhabditis elegans dauer formation pathway. Inoue, T., Thomas, J.H. Genetics (2000) [Pubmed]
A Caenorhabditis elegans model of Yersinia infection: biofilm formation on a biotic surface. Joshua, G.W., Karlyshev, A.V., Smith, M.P., Isherwood, K.E., Titball, R.W., Wren, B.W. Microbiology (Reading, Engl.) (2003) [Pubmed]
Expression cloning of TGF-beta receptors. Lin, H.Y., Wang, X.F. Mol. Reprod. Dev. (1992) [Pubmed]
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans. Krishna, S., Maduzia, L.L., Padgett, R.W. Development (1999) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.