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Gene Review

daf-1  -  Protein DAF-1

Caenorhabditis elegans

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High impact information on daf-1

  • A daf-1 probe detects a 2.5 kb mRNA of low abundance, and the DNA sequence indicates that the gene encodes a 669 amino acid protein, with a putative transmembrane domain and a C-terminal protein kinase domain most closely related to the cytosolic, raf proto-oncogene family [1].
  • To identify additional genes that function in this pathway, we carried out a screen for suppressors of mutations in daf-1, daf-8, and daf-14 [2].
  • These mutants, srf-2, srf-3, srf-5 and the dauer pathway gene daf-1, also exhibit altered binding of lectins to the nematode surface [3].
  • The cloned type II receptor has a predicted protein core of about 60 kDa with a cysteine-rich extracellular domain, a single transmembrane domain, and a functional serine/threonine kinase domain that is homologous to the activin receptor and to the C. elegans protein daf-1 [4].

Analytical, diagnostic and therapeutic context of daf-1

  • In addition, it is also required for body size determination and male tail patterning, roles which do not require daf-1 [5].


  1. daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase. Georgi, L.L., Albert, P.S., Riddle, D.L. Cell (1990) [Pubmed]
  2. Suppressors of transforming growth factor-beta pathway mutants in the Caenorhabditis elegans dauer formation pathway. Inoue, T., Thomas, J.H. Genetics (2000) [Pubmed]
  3. A Caenorhabditis elegans model of Yersinia infection: biofilm formation on a biotic surface. Joshua, G.W., Karlyshev, A.V., Smith, M.P., Isherwood, K.E., Titball, R.W., Wren, B.W. Microbiology (Reading, Engl.) (2003) [Pubmed]
  4. Expression cloning of TGF-beta receptors. Lin, H.Y., Wang, X.F. Mol. Reprod. Dev. (1992) [Pubmed]
  5. Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans. Krishna, S., Maduzia, L.L., Padgett, R.W. Development (1999) [Pubmed]
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