Gene Review:
INHBE - inhibin, beta E
Homo sapiens
Synonyms:
Activin beta-E chain, Inhibin beta E chain, MGC4638, activin
Keutmann,
Schneyer,
Sidis,
Fujii,
Kawakami,
Okada,
Kageyama,
Kihara,
Phillips,
Jones,
McGaw,
Groome,
Smolich,
Pärsson,
de Kretser,
Eldar-Geva,
Spitz,
Groome,
Margalioth,
Homburg,
Jenkin,
Ward,
Loose,
Schneider-Kolsky,
Young,
Canny,
O'Connor,
de Kretser,
Wallace,
Ebert,
Phillips,
Jenzewski,
Nau,
O'connor,
Michel,
Schier,
Dalkin,
Gilrain,
Bradshaw,
Myers,
- Presence of activin, inhibin, and follistatin in epithelial ovarian carcinoma. Welt, C.K., Lambert-Messerlian, G., Zheng, W., Crowley, W.F., Schneyer, A.L. J. Clin. Endocrinol. Metab. (1997)
- Activin A concentrations in human cerebrospinal fluid are age-dependent and elevated in meningitis. Ebert, S., Phillips, D.J., Jenzewski, P., Nau, R., O'connor, A.E., Michel, U. J. Neurol. Sci. (2006)
- Activin effects on neoplastic proliferation of human pituitary tumors. Danila, D.C., Inder, W.J., Zhang, X., Alexander, J.M., Swearingen, B., Hedley-Whyte, E.T., Klibanski, A. J. Clin. Endocrinol. Metab. (2000)
- Expression and localization of activin subunits and follistatins in tissues from men with high grade prostate cancer. Thomas, T.Z., Wang, H., Niclasen, P., O'Bryan, M.K., Evans, L.W., Groome, N.P., Pedersen, J., Risbridger, G.P. J. Clin. Endocrinol. Metab. (1997)
- Id proteins: novel targets of activin action, which regulate epidermal homeostasis. Rotzer, D., Krampert, M., Sulyok, S., Braun, S., Stark, H.J., Boukamp, P., Werner, S. Oncogene (2006)
- Nonsteroidal signals originating in the gonads. Ackland, J.F., Schwartz, N.B., Mayo, K.E., Dodson, R.E. Physiol. Rev. (1992)
- Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling. Wu, J.W., Krawitz, A.R., Chai, J., Li, W., Zhang, F., Luo, K., Shi, Y. Cell (2002)
- Epithelial morphogenesis. Gumbiner, B.M. Cell (1992)
- Nodal signaling in vertebrate development. Schier, A.F. Annu. Rev. Cell Dev. Biol. (2003)
- Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. Lagna, G., Hata, A., Hemmati-Brivanlou, A., Massagué, J. Nature (1996)
- Activin inhibition of prostate cancer cell growth: selective actions on androgen-responsive LNCaP cells. Dalkin, A.C., Gilrain, J.T., Bradshaw, D., Myers, C.E. Endocrinology (1996)
- Follistatin is a developmentally regulated cytokine in neural differentiation. Hashimoto, M., Nakamura, T., Inoue, S., Kondo, T., Yamada, R., Eto, Y., Sugino, H., Muramatsu, M. J. Biol. Chem. (1992)
- Release of activin and follistatin during cardiovascular procedures is largely due to heparin administration. Phillips, D.J., Jones, K.L., McGaw, D.J., Groome, N.P., Smolich, J.J., Pärsson, H., de Kretser, D.M. J. Clin. Endocrinol. Metab. (2000)
- Two distinct signaling pathways activated by activin A in glucose-responsive pancreatic beta-cell lines. Shibata, H., Kanzaki, M., Takeuchi, T., Miyazaki, J., Kojima, I. J. Mol. Endocrinol. (1996)
- Physiological and regulatory roles of activin A in late pregnancy. Jenkin, G., Ward, J., Loose, J., Schneider-Kolsky, M., Young, R., Canny, B., O'Connor, A., de Kretser, D., Wallace, E. Mol. Cell. Endocrinol. (2001)
- Biological activity of follistatin isoforms and follistatin-like-3 is dependent on differential cell surface binding and specificity for activin, myostatin, and bone morphogenetic proteins. Sidis, Y., Mukherjee, A., Keutmann, H., Delbaere, A., Sadatsuki, M., Schneyer, A. Endocrinology (2006)
- Follistatin production by skin fibroblasts and its regulation by dexamethasone. Kawakami, S., Fujii, Y., Winters, S.J. Mol. Cell. Endocrinol. (2001)
- Expression of activin and inhibin subunits, receptors and binding proteins in Human adrenocortical neoplasms. Hofland, J., Timmerman, M.A., de Herder, W.W., van Schaik, R.H., de Krijger, R.R., de Jong, F.H. Clin. Endocrinol. (Oxf) (2006)
- Follistatin and activin A serum concentrations in obese and non-obese patients with polycystic ovary syndrome. Eldar-Geva, T., Spitz, I.M., Groome, N.P., Margalioth, E.J., Homburg, R. Hum. Reprod. (2001)
- A novel role of follistatin, an activin-binding protein, in the inhibition of activin action in rat pituitary cells. Endocytotic degradation of activin and its acceleration by follistatin associated with cell-surface heparan sulfate. Hashimoto, O., Nakamura, T., Shoji, H., Shimasaki, S., Hayashi, Y., Sugino, H. J. Biol. Chem. (1997)
- The role of follistatin domains in follistatin biological action. Keutmann, H.T., Schneyer, A.L., Sidis, Y. Mol. Endocrinol. (2004)
- Analysis of human follistatin structure: identification of two discontinuous N-terminal sequences coding for activin A binding and structural consequences of activin binding to native proteins. Wang, Q., Keutmann, H.T., Schneyer, A.L., Sluss, P.M. Endocrinology (2000)
- Alpha 2-macroglobulin is a binding protein of inhibin and activin. Vaughan, J.M., Vale, W.W. Endocrinology (1993)
- Identification of a functional binding site for activin on the type I receptor ALK4. Harrison, C.A., Gray, P.C., Koerber, S.C., Fischer, W., Vale, W. J. Biol. Chem. (2003)
- Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells. Burdette, J.E., Jeruss, J.S., Kurley, S.J., Lee, E.J., Woodruff, T.K. Cancer Res. (2005)
- Regulation of follistatin production by rat granulosa cells in vitro. Shintani, Y., Dyson, M., Drummond, A.E., Findlay, J.K. Endocrinology (1997)
- Crucial role of activin a in tubulogenesis of endothelial cells induced by vascular endothelial growth factor. Maeshima, K., Maeshima, A., Hayashi, Y., Kishi, S., Kojima, I. Endocrinology (2004)
- Regulation of prostate-specific antigen by activin A in prostate cancer LNCaP cells. Fujii, Y., Kawakami, S., Okada, Y., Kageyama, Y., Kihara, K. Am. J. Physiol. Endocrinol. Metab. (2004)
- The secretion and effect of inhibin A, activin A and follistatin on first-trimester trophoblasts in vitro. Bearfield, C., Jauniaux, E., Groome, N., Sargent, I.L., Muttukrishna, S. Eur. J. Endocrinol. (2005)
- Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function. Bartholin, L., Maguer-Satta, V., Hayette, S., Martel, S., Gadoux, M., Corbo, L., Magaud, J.P., Rimokh, R. Oncogene (2002)
- Activin and follistatin as local regulators in the human ovary. Peng, C., Ohno, T., Khorasheh, S., Leung, P.C. Biol. Signals (1996)
- Novel action of activin and bone morphogenetic protein in regulating aldosterone production by human adrenocortical cells. Suzuki, J., Otsuka, F., Inagaki, K., Takeda, M., Ogura, T., Makino, H. Endocrinology (2004)
- Presence of activin (erythroid differentiation factor) in unfertilized eggs and blastulae of Xenopus laevis. Asashima, M., Nakano, H., Uchiyama, H., Sugino, H., Nakamura, T., Eto, Y., Ejima, D., Nishimatsu, S., Ueno, N., Kinoshita, K. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Follistatin: essential role for the N-terminal domain in activin binding and neutralization. Sidis, Y., Schneyer, A.L., Sluss, P.M., Johnson, L.N., Keutmann, H.T. J. Biol. Chem. (2001)
- Identification of activins and follistatin proteins in human follicular fluid and placenta. Yokoyama, Y., Nakamura, T., Nakamura, R., Irahara, M., Aono, T., Sugino, H. J. Clin. Endocrinol. Metab. (1995)
- Expression of activin A and follistatin core proteins by human prostate tumor cell lines. McPherson, S.J., Mellor, S.L., Wang, H., Evans, L.W., Groome, N.P., Risbridger, G.P. Endocrinology (1999)