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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

str-2  -  Protein STR-2

Caenorhabditis elegans

 
 
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Psychiatry related information on str-2

  • A cGMP signaling pathway that is used in olfaction maintains str-2 expression after the initial decision has been made [1].
 

High impact information on str-2

  • This interaction induces str-2 expression by reducing calcium signaling through a voltage-dependent Ca2+ channel and the CaM kinase II UNC-43 [1].
  • Expression of two receptor genes is regulated by developmental entry into the dauer larva stage. srd-1 expression in ASI neurons is repressed in dauer larvae. str-2 expression in dauer animals is induced in the ASI neurons, but repressed in the AWC neurons [2].
  • Three predicted chemosensory receptor genes expressed in the ASI chemosensory neurons, srd-1, str-2, and str-3, are repressed by exposure to the dauer pheromone, a signal of crowding [2].
  • Noncell- and cell-autonomous G-protein-signaling converges with Ca2+/mitogen-activated protein kinase signaling to regulate str-2 receptor gene expression in Caenorhabditis elegans [3].
 

Other interactions of str-2

  • In addition, ASI expression of srd-1, but not str-2 and str-3, is induced by sensory activity of the ASI neurons [2].

References

  1. Lateral signaling mediated by axon contact and calcium entry regulates asymmetric odorant receptor expression in C. elegans. Troemel, E.R., Sagasti, A., Bargmann, C.I. Cell (1999) [Pubmed]
  2. Sensory experience and sensory activity regulate chemosensory receptor gene expression in Caenorhabditis elegans. Peckol, E.L., Troemel, E.R., Bargmann, C.I. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. Noncell- and cell-autonomous G-protein-signaling converges with Ca2+/mitogen-activated protein kinase signaling to regulate str-2 receptor gene expression in Caenorhabditis elegans. Lans, H., Jansen, G. Genetics (2006) [Pubmed]
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