Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

vha-19 - Protein VHA-19

Caenorhabditis elegans

Perego, C. et al., Portereiko, M.F. et al., Hoier, E.F. et al.

Perego, Vanoni, Massari, Longhi, Pietrini,

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High impact information on vha-19

In this process, APR-1 may act in a Cadherin/alpha-Catenin/beta-Catenin complex as a component of adherens junctions [1].
The presence of beta-catenin at the junction is required in order to relocate LIN-7 from the cytosol to cadherin-mediated adhesions, thus indicating that LIN-7 junctional recruitment is beta-catenin dependent and that one functional role of the binding is to localize LIN-7 [2].
Affected proteins include PAR-3/Bazooka and PKC-3/atypical protein kinase C at the apical membrane domain, and HMR-1/cadherin and AJM-1 within C. elegans apical junctions (CeAJ) [3].

Associations of vha-19 with chemical compounds

The association of LIN-7 with cadherin and beta-catenin is Ca(2+) dependent and is mediated by the direct binding of LIN-7 to the C-terminal PDZ target sequence of beta-catenin, as demonstrated by means of co-immunoprecipitation experiments and in vitro binding assays with the recombinant glutathione S-transferase:LIN-7A [2].

Other interactions of vha-19

We report here that mammalian LIN-7 PDZ proteins form a complex with cadherin and beta-catenin in epithelia and neurons [2].

References

The Caenorhabditis elegans APC-related gene apr-1 is required for epithelial cell migration and Hox gene expression. Hoier, E.F., Mohler, W.A., Kim, S.K., Hajnal, A. Genes Dev. (2000) [Pubmed]
Mammalian LIN-7 PDZ proteins associate with beta-catenin at the cell-cell junctions of epithelia and neurons. Perego, C., Vanoni, C., Massari, S., Longhi, R., Pietrini, G. EMBO J. (2000) [Pubmed]
ZEN-4/MKLP1 is required to polarize the foregut epithelium. Portereiko, M.F., Saam, J., Mango, S.E. Curr. Biol. (2004) [Pubmed]

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