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Gene Review

ced-5  -  Protein CED-5

Caenorhabditis elegans

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High impact information on ced-5

  • The expression of human DOCK180 in C. elegans rescued the cell-migration defect of a ced-5 mutant [1].
  • We suggest that ced-5 acts in the extension of the surface of an engulfing cell around a dying cell during programmed cell death [1].
  • Mutations in genes in one of these pathways, defined by the genes ced-2, ced-5 and ced-10, result in defects both in the engulfment of dying cells and in the migrations of the two distal tip cells of the developing gonad [2].
  • The gene products of ced-2, ced-5, and ced-10 are thought to be part of a pathway that regulates the reorganization of the cytoskeleton during engulfment [3].
  • The highest concentration was found in the ced-5; ced-7 double phagocytosis mutants which carry an extra number of dead cells during their lifespan [4].

Other interactions of ced-5

  • However, neither ced-2/crkII nor ced-5/dock180 is involved in amphid axon outgrowth [5].


  1. C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180. Wu, Y.C., Horvitz, H.R. Nature (1998) [Pubmed]
  2. CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Reddien, P.W., Horvitz, H.R. Nat. Cell Biol. (2000) [Pubmed]
  3. Evidence for a conserved role for CRKII and Rac in engulfment of apoptotic cells. Tosello-Trampont, A.C., Brugnera, E., Ravichandran, K.S. J. Biol. Chem. (2001) [Pubmed]
  4. Biochemical characterization and localization of transglutaminase in wild-type and cell-death mutants of the nematode Caenorhabditis elegans. Mádi, A., Punyiczki, M., di Rao, M., Piacentini, M., Fésüs, L. Eur. J. Biochem. (1998) [Pubmed]
  5. Distinct rac activation pathways control Caenorhabditis elegans cell migration and axon outgrowth. Wu, Y.C., Cheng, T.W., Lee, M.C., Weng, N.Y. Dev. Biol. (2002) [Pubmed]
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