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Gene Review:

glc-3 - Protein GLC-3

Caenorhabditis elegans

Horoszok, L. et al., Smith, M.M. et al.

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High impact information on glc-3

NA activates a glutamate-gated chloride channel (GluCl) in grasshopper neurons and potentiates channel opening by glutamate [1].
2. Expression of glc-3 cRNA in XENOPUS oocytes resulted in the formation of homo-oligomeric L-glutamate-gated chloride channels with robust and rapidly desensitizing currents, an EC(50) of 1.9+/-0.03 mM and a Hill coefficient of 1.5+/-0 [2].
1. We report the cloning and expression of a novel Caenorhabditis elegans polypeptide, GLC-3, with high sequence identity to previously cloned L-glutamate-gated chloride channel subunits from nematodes and insects [2].
GLC-3: a novel fipronil and BIDN-sensitive, but picrotoxinin-insensitive, L-glutamate-gated chloride channel subunit from Caenorhabditis elegans [2].

References

Nodulisporic acid opens insect glutamate-gated chloride channels: identification of a new high affinity modulator. Smith, M.M., Warren, V.A., Thomas, B.S., Brochu, R.M., Ertel, E.A., Rohrer, S., Schaeffer, J., Schmatz, D., Petuch, B.R., Tang, Y.S., Meinke, P.T., Kaczorowski, G.J., Cohen, C.J. Biochemistry (2000) [Pubmed]
GLC-3: a novel fipronil and BIDN-sensitive, but picrotoxinin-insensitive, L-glutamate-gated chloride channel subunit from Caenorhabditis elegans. Horoszok, L., Raymond, V., Sattelle, D.B., Wolstenholme, A.J. Br. J. Pharmacol. (2001) [Pubmed]

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AgaP_AGAP001434	Anopheles gambiae str. PEST
GLRA1	Bos taurus
avr-15	Caenorhabditis elegans
avr-15	Caenorhabditis elegans
glc-1	Caenorhabditis elegans
avr-14	Caenorhabditis elegans
GLRA1	Canis lupus familiaris
glra1	Danio rerio
GluClalpha	Drosophila melanogaster
GLRA1	Gallus gallus
GLRA1	Homo sapiens
GLRA1	Macaca mulatta
Glra1	Mus musculus
GLRA1	Pan troglodytes
Glra1	Rattus norvegicus
glra1	Xenopus (Silurana) tropicalis

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