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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

glc-1  -  Protein GLC-1

Caenorhabditis elegans

 
 
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Disease relevance of glc-1

  • We constructed a three-cistron Sindbis virus that expresses the alpha and beta subunits of a glutamate-gated chloride channel (GluCl) along with the green fluorescent protein (EGFP) marker [1].
 

High impact information on glc-1

  • A C. elegans messenger RNA expressed in Xenopus oocytes encodes an avermectin-sensitive glutamate-gated chloride channel [2].
  • An amino acid substitution in the pore region of a glutamate-gated chloride channel enables the coupling of ligand binding to channel gating [3].
  • The nematocidal drug ivermectin is believed to kill worms by opening a glutamate-gated chloride channel (AVR-15) on pharyngeal muscle, causing complete pumping inhibition [4].
  • Glutamate-gated chloride channels, with electrophysiological properties similar to GluClalpha and GluClbeta, have been described in insects and crustaceans, suggesting that the glutamate-gated chloride channel family may be conserved in other invertebrate species [5].
  • A glutamate-gated chloride channel subunit from Haemonchus contortus: expression in a mammalian cell line, ligand binding, and modulation of anthelmintic binding by glutamate [6].

References

  1. Selective electrical silencing of mammalian neurons in vitro by the use of invertebrate ligand-gated chloride channels. Slimko, E.M., McKinney, S., Anderson, D.J., Davidson, N., Lester, H.A. J. Neurosci. (2002) [Pubmed]
  2. Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. Cully, D.F., Vassilatis, D.K., Liu, K.K., Paress, P.S., Van der Ploeg, L.H., Schaeffer, J.M., Arena, J.P. Nature (1994) [Pubmed]
  3. An amino acid substitution in the pore region of a glutamate-gated chloride channel enables the coupling of ligand binding to channel gating. Etter, A., Cully, D.F., Schaeffer, J.M., Liu, K.K., Arena, J.P. J. Biol. Chem. (1996) [Pubmed]
  4. Mechanosensory inputs influence Caenorhabditis elegans pharyngeal activity via ivermectin sensitivity genes. Keane, J., Avery, L. Genetics (2003) [Pubmed]
  5. Evolutionary relationship of the ligand-gated ion channels and the avermectin-sensitive, glutamate-gated chloride channels. Vassilatis, D.K., Elliston, K.O., Paress, P.S., Hamelin, M., Arena, J.P., Schaeffer, J.M., Van der Ploeg, L.H., Cully, D.F. J. Mol. Evol. (1997) [Pubmed]
  6. A glutamate-gated chloride channel subunit from Haemonchus contortus: expression in a mammalian cell line, ligand binding, and modulation of anthelmintic binding by glutamate. Forrester, S.G., Prichard, R.K., Beech, R.N. Biochem. Pharmacol. (2002) [Pubmed]
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