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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

avr-14  -  Protein AVR-14

Caenorhabditis elegans

 
 
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High impact information on avr-14

  • Although the alternative splicing of avr-14 is conserved across the species, the processing of the mature GluClalpha3A mRNA differs in D. immitis compared to C. elegans and H. contortus [1].
  • The alternatively-spliced Caenorhabditis elegans gbr-2/avr-14 gene encodes two subunits of the nematode ligand-gated chloride channel family which forms an important molecular target for the avermectin and related anthelminthics [2].
 

Analytical, diagnostic and therapeutic context of avr-14

References

  1. An ivermectin-sensitive glutamate-gated chloride channel subunit from Dirofilaria immitis. Yates, D.M., Wolstenholme, A.J. Int. J. Parasitol. (2004) [Pubmed]
  2. Ligand-gated chloride channel subunits encoded by the Haemonchus contortus and Ascaris suum orthologues of the Caenorhabditis elegans gbr-2 (avr-14) gene. Jagannathan, S., Laughton, D.L., Critten, C.L., Skinner, T.M., Horoszok, L., Wolstenholme, A.J. Mol. Biochem. Parasitol. (1999) [Pubmed]
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