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Gene Review:

mdf-1 - Protein MDF-1

Caenorhabditis elegans

Kitagawa, R. et al., Furuta, T. et al.

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Disease relevance of mdf-1

A reduction in emb-30 activity can suppress the lethality and sterility caused by a null mutation in mdf-1, a component of the spindle assembly checkpoint machinery [1].

High impact information on mdf-1

Here we show that mdf-1 and mdf-2 are components of the spindle-assembly checkpoint in Caenorhabditis elegans, and are essential for the long-term survival and fertility of this organism [2].
Antibodies that recognize the MDF-2 protein localize to nuclei of the cleaving embryo in a cell-cycle-dependent manner. mdf-1, a gene encoding a product that interacts with MDF-2, is required for cell-cycle arrest and proper chromosome segregation in premeiotic germ cells treated with nocodazole, a microtubule-depolymerizing agent [2].

References

EMB-30: an APC4 homologue required for metaphase-to-anaphase transitions during meiosis and mitosis in Caenorhabditis elegans. Furuta, T., Tuck, S., Kirchner, J., Koch, B., Auty, R., Kitagawa, R., Rose, A.M., Greenstein, D. Mol. Biol. Cell (2000) [Pubmed]
Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans. Kitagawa, R., Rose, A.M. Nat. Cell Biol. (1999) [Pubmed]

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