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Gene Review

cnb-1  -  Protein CNB-1

Caenorhabditis elegans

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High impact information on cnb-1

  • Calcineurin is expressed in hypodermal seam cells, body-wall muscle, vulva muscle, neuronal cells, and in sperm and the spermatheca. cnb-1 mutants showed pleiotropic defects including lethargic movement and delayed egg-laying [1].
  • In Caenorhabditis elegans, tax-6 and cnb-1 encode catalytic and regulatory subunits of calcineurin, respectively [2].


  1. Calcineurin, a calcium/calmodulin-dependent protein phosphatase, is involved in movement, fertility, egg laying, and growth in Caenorhabditis elegans. Bandyopadhyay, J., Lee, J., Lee, J., Lee, J.I., Yu, J.R., Jee, C., Cho, J.H., Jung, S., Lee, M.H., Zannoni, S., Singson, A., Kim, d.o. .H., Koo, H.S., Ahnn, J. Mol. Biol. Cell (2002) [Pubmed]
  2. Calcineurin interacts with KIN-29, a Ser/Thr kinase, in Caenorhabditis elegans. Singaravelu, G., Song, H.O., Ji, Y.J., Jee, C., Park, B.J., Ahnn, J. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
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