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Gene Review

Ppp3r1  -  protein phosphatase 3, regulatory subunit...

Mus musculus

Synonyms: CaNB1, Calcineurin subunit B type 1, Cnb, Cnb1, MCIP1, ...
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Disease relevance of Ppp3r1


High impact information on Ppp3r1

  • In these mice, calcineurin function is removed by the selective deletion of Cnb1 in the mesenchyme of the developing urinary tract using the Cre/lox system [2].
  • However, the protein kinases that function downstream of MEKK3 to mediate MCIP1 phosphorylation and the mechanism of MCIP1-mediated calcineurin regulation have not been defined [3].
  • In neonatal cultured cardiac myocytes, inhibition of GCA by HS142-1 (100 microg/mL) increased basal and phenylephrine (10(-6) mol/L)-stimulated calcineurin activity, nuclear translocation of NFATc3, and MCIP1 mRNA expression [4].
  • METHODS AND RESULTS: At 14 weeks of age, calcineurin activity, nuclear translocation of nuclear factor of activated T cells c3 (NFATc3), and modulatory calcineurin-interacting protein 1 (MCIP1) gene expressions were increased in the hearts of GCA-KO mice compared with wild-type (WT) mice [4].
  • To address these questions, transgenic (TG) mice engineered to overexpress modulatory calcineurin-interacting protein-1 (MCIP1) in the myocardium were used to achieve cardiac-specific inhibition of calcineurin activation [1].

Biological context of Ppp3r1

  • In summary, our findings reveal a previously unrecognized essential regulatory role of mitogen-activated protein kinase signaling in calcineurin activation through the reversible phosphorylation of a calcineurin-interacting protein, MCIP1 [3].


  1. MCIP1 overexpression suppresses left ventricular remodeling and sustains cardiac function after myocardial infarction. van Rooij, E., Doevendans, P.A., Crijns, H.J., Heeneman, S., Lips, D.J., van Bilsen, M., Williams, R.S., Olson, E.N., Bassel-Duby, R., Rothermel, B.A., De Windt, L.J. Circ. Res. (2004) [Pubmed]
  2. Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery. Chang, C.P., McDill, B.W., Neilson, J.R., Joist, H.E., Epstein, J.A., Crabtree, G.R., Chen, F. J. Clin. Invest. (2004) [Pubmed]
  3. Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1. Abbasi, S., Lee, J.D., Su, B., Chen, X., Alcon, J.L., Yang, J., Kellems, R.E., Xia, Y. J. Biol. Chem. (2006) [Pubmed]
  4. Calcineurin-nuclear factor of activated T cells pathway-dependent cardiac remodeling in mice deficient in guanylyl cyclase A, a receptor for atrial and brain natriuretic peptides. Tokudome, T., Horio, T., Kishimoto, I., Soeki, T., Mori, K., Kawano, Y., Kohno, M., Garbers, D.L., Nakao, K., Kangawa, K. Circulation (2005) [Pubmed]
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