High impact information on CanB

• Three clones encoded a 19.3-kDa protein whose sequence is 88% identical to that of human calcineurin B, the Ca(2+)-binding regulatory subunit of calcineurin [1].
• Drosophila calcineurin B is the product of a single intron-less gene located at position 4F on the X chromosome [1].
• The deduced amino acid sequence well conserves four EF-hand type calcium-binding structures, showing 95% and about 85% identities to D. melanogaster CnB and mammalian CnBs, respectively [2].
• A homology search revealed that these were similar to a protein encoded in an open reading frame near the calcineurin B subunit gene on chromosome XI in Saccharomyces cerevisiae [3].

Analytical, diagnostic and therapeutic context of CanB

• Northern blot analyses revealed that both CnA and CnB genes were expressed in various larval and adult tissues of B. mori [2].

References