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Gene Review:

DPH2 - DPH2 homolog (S. cerevisiae)

Homo sapiens

Synonyms: DPH2 homolog, DPH2-like 2, DPH2L2, Diphthamide biosynthesis protein 2, Diphthamide biosynthesis protein 2 homolog-like 2, ...

Mattheakis, L.C. et al., Liu, S. et al., Phillips, N.J. et al., Schultz, D.C. et al.

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Disease relevance of DPH2

This conclusion was supported by Northern blot analysis of the DPH2 transcript and gel analysis of the DPH2 protein overproduced in Escherichia coli [1].

High impact information on DPH2

The human tumor suppressor gene OVCA1, previously identified as homologous to yeast DPH2, is shown to actually be HsDPH1 [2].
Dph2 and Dph5 were previously identified [2].
Diphthamide synthesis in Saccharomyces cerevisiae: structure of the DPH2 gene [1].
DPH2 exists as a single-copy gene in the yeast genome and is located on the left arm of chromosome XI [1].

Biological context of DPH2

Based on amino acid sequence analysis, the 489-amino-acid protein encoded by this novel gene is distinct from OVCA1 and is more closely related to the yeast dph2 gene product [3].

Associations of DPH2 with chemical compounds

This highly conserved gene has significant sequence similarity to a yeast gene of unknown function and to one of the yeast enzymes in the diphthamide synthetic pathway, DPH2, that has a role in global protein synthesis regulation [4].

Analytical, diagnostic and therapeutic context of DPH2

Sequence analysis of the DPH2 locus predicts that the DPH2 gene product is a 534-amino acid (aa) protein, with a calculated M(r) of 59,772 [1].

References

Diphthamide synthesis in Saccharomyces cerevisiae: structure of the DPH2 gene. Mattheakis, L.C., Sor, F., Collier, R.J. Gene (1993) [Pubmed]
Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. Liu, S., Milne, G.T., Kuremsky, J.G., Fink, G.R., Leppla, S.H. Mol. Cell. Biol. (2004) [Pubmed]
Cloning and localization of a human diphthamide biosynthesis-like protein-2 gene, DPH2L2. Schultz, D.C., Balasara, B.R., Testa, J.R., Godwin, A.K. Genomics (1998) [Pubmed]
A cDNA from the ovarian cancer critical region of deletion on chromosome 17p13.3. Phillips, N.J., Zeigler, M.R., Deaven, L.L. Cancer Lett. (1996) [Pubmed]

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