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Gene Review

arr-1  -  Protein ARR-1

Caenorhabditis elegans

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High impact information on beta-arrestin

  • ARR-1 is primarily expressed in the nervous system, including the HSN neuron and various chemosensory neurons involved in detecting soluble and volatile odorants. arr-1 null mutants exhibit normal chemotaxis but have significant defects in olfactory adaptation and recovery to volatile odorants [1].
  • Overexpression of a dominant-negative dynamin mutant (DynK44A), but not of a dominant-negative beta-arrestin mutant (Arr319-418), substantially inhibited carbachol-induced internalization of GAR-3 [2].


  1. Caenorhabditus elegans arrestin regulates neural G protein signaling and olfactory adaptation and recovery. Palmitessa, A., Hess, H.A., Bany, I.A., Kim, Y.M., Koelle, M.R., Benovic, J.L. J. Biol. Chem. (2005) [Pubmed]
  2. Agonist-induced internalization of the Caenorhabditis elegans muscarinic acetylcholine receptor GAR-3 in Chinese hamster ovary cells. Choi, B., Park, Y.S., Cho, N.J. Neurochem. Res. (2006) [Pubmed]
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