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Gene Review

krz  -  kurtz

Drosophila melanogaster

Synonyms: 0952/14, CG1487, Dmel\CG1487, Krz, Kurz, ...
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High impact information on krz

  • Two genes, scribble and kurtz/modulo, affect the cellular organization of the fat body, the tissue responsible for antimicrobial peptide production [1].
  • Mutations in krz have a broad lethal phase extending from late embryogenesis to the third larval instar [2].
  • Both the behavioral and electrophysiological phenotypes were rescued by the targeted expression of the krz cDNA within postdevelopmental ORNs [3].
  • The rescued krz(1) homozygotes have an incompletely penetrant antennal structural defect that was completely rescued by the neural expression of a krz cDNA [3].
  • Drosophila melanogaster has a single nonvisual arrestin, kurtz, which is found at high levels within the adult olfactory receptor neurons (ORNs), suggesting a role for this gene in modulating olfactory sensitivity [3].

Anatomical context of krz


  1. Drosophila immunity: genes on the third chromosome required for the response to bacterial infection. Wu, L.P., Choe, K.M., Lu, Y., Anderson, K.V. Genetics (2001) [Pubmed]
  2. kurtz, a novel nonvisual arrestin, is an essential neural gene in Drosophila. Roman, G., He, J., Davis, R.L. Genetics (2000) [Pubmed]
  3. A Drosophila nonvisual arrestin is required for the maintenance of olfactory sensitivity. Ge, H., Krishnan, P., Liu, L., Krishnan, B., Davis, R.L., Hardin, P.E., Roman, G. Chem. Senses (2006) [Pubmed]
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