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Gene Review

Arrb1  -  arrestin, beta 1

Rattus norvegicus

Synonyms: Arrestin beta-1, Beta-arrestin-1
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Disease relevance of Arrb1


High impact information on Arrb1

  • beta-Adrenergic receptor kinase (beta ARK) and beta-arrestin function in the homologous or agonist-activated desensitization of G protein-coupled receptors [5].
  • Arf6 activation releases docked beta-arrestin necessary for receptor desensitization, providing a feedback mechanism for receptor self-regulation [6].
  • When endogenous beta-arrestin-1 was knocked down by transfection of beta-arrestin-1 small interfering RNA, insulin-induced IRS-1 degradation was enhanced [7].
  • beta-arrestin-1 is an adaptor protein that mediates agonist-dependent internalization and desensitization of G-protein-coupled receptors (GPCRs) and also participates in the process of heterologous desensitization between receptor tyrosine kinases and GPCR signaling [7].
  • In addition, insulin-like growth factor I receptor (IGF-IR) endocytosis is facilitated by beta-arrestin-1, and internalization is necessary for IGF-I-stimulated mitogen-activated protein (MAP) kinase activation [8].

Biological context of Arrb1


Anatomical context of Arrb1


Associations of Arrb1 with chemical compounds


Regulatory relationships of Arrb1


Other interactions of Arrb1


Analytical, diagnostic and therapeutic context of Arrb1


  1. Myocardial distribution and regulation of GRK and beta-arrestin isoforms in congestive heart failure in rats. Vinge, L.E., Øie, E., Andersson, Y., Grøgaard, H.K., Andersen, G., Attramadal, H. Am. J. Physiol. Heart Circ. Physiol. (2001) [Pubmed]
  2. Hypoxia/ischemia modulates G protein-coupled receptor kinase 2 and beta-arrestin-1 levels in the neonatal rat brain. Lombardi, M.S., van den Tweel, E., Kavelaars, A., Groenendaal, F., van Bel, F., Heijnen, C.J. Stroke (2004) [Pubmed]
  3. Nerve growth factor signaling involves interaction between the Trk A receptor and lysophosphatidate receptor 1 systems: nuclear translocation of the lysophosphatidate receptor 1 and Trk A receptors in pheochromocytoma 12 cells. Moughal, N.A., Waters, C., Sambi, B., Pyne, S., Pyne, N.J. Cell. Signal. (2004) [Pubmed]
  4. Expression patterns of the regulatory proteins G protein-coupled receptor kinase 2 and beta-arrestin 1 during rat postnatal brain development: effect of hypothyroidism. Penela, P., Alvarez-Dolado, M., Muñoz, A., Mayor, F. Eur. J. Biochem. (2000) [Pubmed]
  5. Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization. Dawson, T.M., Arriza, J.L., Jaworsky, D.E., Borisy, F.F., Attramadal, H., Lefkowitz, R.J., Ronnett, G.V. Science (1993) [Pubmed]
  6. The ADP ribosylation factor nucleotide exchange factor ARNO promotes beta-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization. Mukherjee, S., Gurevich, V.V., Jones, J.C., Casanova, J.E., Frank, S.R., Maizels, E.T., Bader, M.F., Kahn, R.A., Palczewski, K., Aktories, K., Hunzicker-Dunn, M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  7. beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1. Usui, I., Imamura, T., Huang, J., Satoh, H., Shenoy, S.K., Lefkowitz, R.J., Hupfeld, C.J., Olefsky, J.M. Mol. Cell. Biol. (2004) [Pubmed]
  8. Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1. Dalle, S., Imamura, T., Rose, D.W., Worrall, D.S., Ugi, S., Hupfeld, C.J., Olefsky, J.M. Mol. Cell. Biol. (2002) [Pubmed]
  9. Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization. Zhang, J., Ferguson, S.S., Barak, L.S., Ménard, L., Caron, M.G. J. Biol. Chem. (1996) [Pubmed]
  10. Cutting edge: Differential regulation of chemoattractant receptor-induced degranulation and chemokine production by receptor phosphorylation. Ahamed, J., Haribabu, B., Ali, H. J. Immunol. (2001) [Pubmed]
  11. Beta-adrenergic receptor kinase-like activity and beta-arrestin are expressed in osteoblastic cells. Bliziotes, M., Murtagh, J., Wiren, K. J. Bone Miner. Res. (1996) [Pubmed]
  12. Upregulation of beta-adrenergic receptors in heart failure due to volume overload. Wang, X., Sentex, E., Saini, H.K., Chapman, D., Dhalla, N.S. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  13. Potential regulatory roles for G protein-coupled receptor kinases and beta-arrestins in gonadotropin-releasing hormone receptor signaling. Neill, J.D., Duck, L.W., Musgrove, L.C., Sellers, J.C. Endocrinology (1998) [Pubmed]
  14. Presence of beta-arrestin-1 immunoreactivity in the cutaneous nerve fibers of rat glabrous skin. Komori, N., Neal, J., Cain, S.D., Logan, J., Wirsig, C., Miller, K.E. Brain Res. (2003) [Pubmed]
  15. Activation of beta-adrenergic receptor kinase during myocardial ischemia. Ungerer, M., Kessebohm, K., Kronsbein, K., Lohse, M.J., Richardt, G. Circ. Res. (1996) [Pubmed]
  16. Impaired renal sensory responses after renal ischemia in the rat. Ma, M.C., Huang, H.S., Wu, M.S., Chien, C.T., Chen, C.F. J. Am. Soc. Nephrol. (2002) [Pubmed]
  17. Phosphorylation-independent beta-arrestin translocation and internalization of leukotriene B4 receptors. Jala, V.R., Shao, W.H., Haribabu, B. J. Biol. Chem. (2005) [Pubmed]
  18. Presence of beta-arrestin in cellular inclusions in metamphetamine-treated PC12 cells. De Blasi, A., Capobianco, L., Iacovelli, L., Lenzi, P., Ferrucci, M., Lazzeri, G., Fornai, F., Picascia, A. Neurol. Sci. (2003) [Pubmed]
  19. Differential regulation of beta-arrestin 1 and beta-arrestin 2 gene expression in rat brain by morphine. Fan, X.L., Zhang, J.S., Zhang, X.Q., Yue, W., Ma, L. Neuroscience (2003) [Pubmed]
  20. The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins. Schmidlin, F., Roosterman, D., Bunnett, N.W. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  21. Nerve growth factor stimulation of p42/p44 mitogen-activated protein kinase in PC12 cells: role of G(i/o), G protein-coupled receptor kinase 2, beta-arrestin I, and endocytic processing. Rakhit, S., Pyne, S., Pyne, N.J. Mol. Pharmacol. (2001) [Pubmed]
  22. The rat gonadotropin-releasing hormone receptor internalizes via a beta-arrestin-independent, but dynamin-dependent, pathway: addition of a carboxyl-terminal tail confers beta-arrestin dependency. Heding, A., Vrecl, M., Hanyaloglu, A.C., Sellar, R., Taylor, P.L., Eidne, K.A. Endocrinology (2000) [Pubmed]
  23. Effect of hypothyroidism on G protein-coupled receptor kinase 2 expression levels in rat liver, lung, and heart. Penela, P., Barradas, M., Alvarez-Dolado, M., Muñoz, A., Mayor, F. Endocrinology (2001) [Pubmed]
  24. Structure and function of the third intracellular loop of the 5-hydroxytryptamine2A receptor: the third intracellular loop is alpha-helical and binds purified arrestins. Gelber, E.I., Kroeze, W.K., Willins, D.L., Gray, J.A., Sinar, C.A., Hyde, E.G., Gurevich, V., Benovic, J., Roth, B.L. J. Neurochem. (1999) [Pubmed]
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