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Gene Review

Arrb1  -  arrestin, beta 1

Mus musculus

Synonyms: 1200006I17Rik, AW208571, Arrestin beta-1, Beta-arrestin-1, G430100A01Rik, ...
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Disease relevance of Arrb1


High impact information on Arrb1

  • Here, we establish that GRK/beta-arrestin-mediated signal transduction via the angiotensin II (ANG) type 1A receptor (AT(1A)R) results in positive inotropic and lusitropic effects in isolated adult mouse cardiomyocytes [2].
  • beta-Arrestin 1 is required for internalization and mitogen-activated protein (MAP) kinase activation by the beta2 adrenergic receptor (beta2AR) [3].
  • Our previous studies have shown that chronic insulin treatment down-regulates cellular beta-arrestin 1 levels, leading to a marked impairment in G protein-coupled receptor and insulin-like growth factor-1 receptor-mediated MAP kinase and mitogenic signaling [3].
  • Comparison of the ability of the two beta-arrestins to sequester the beta(2)-AR revealed beta-arrestin 2 to be 100-fold more potent than beta-arrestin 1 [4].
  • To better define differences in the roles of beta-arrestin 1 and 2, we prepared mouse embryonic fibroblasts from knockout mice that lack one of the beta-arrestins (beta arr1-KO and beta arr2-KO) or both (beta arr1/2-KO), as well as their wild-type (WT) littermate controls [4].

Biological context of Arrb1


Anatomical context of Arrb1

  • The results show conclusively that receptor dephosphorylation can take place on the plasma membrane and that beta-arrestin binding is critical for desensitization and internalization [5].
  • Overexpression of beta-arrestin in endothelial cells decreased colocalization with Rab7 [1].
  • Stimulation of M2 mAChRs led to a stable co-localization with GFP-tagged beta-arrestin within endocytic structures in multiple cell lines; the compartment to which beta-arrestin localized was determined to be the early endosome [9].

Associations of Arrb1 with chemical compounds

  • For example, morphine binding produces a muOR with low affinity for beta-arrestin proteins and limited receptor internalization, whereas enkephalin analogs promote robust trafficking of both beta-arrestins and the receptors [10].
  • To begin to dissect the mechanisms involved in the 24-h cyclical regulation of GnRH transcription, we have found that melatonin (10 nM) induces rapid internalization of membrane-bound mt1 receptors through a beta-arrestin 1-mediated mechanism [11].

Regulatory relationships of Arrb1


Other interactions of Arrb1


  1. beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae. Radin, J.N., Orihuela, C.J., Murti, G., Guglielmo, C., Murray, P.J., Tuomanen, E.I. Infect. Immun. (2005) [Pubmed]
  2. beta-Arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. Rajagopal, K., Whalen, E.J., Violin, J.D., Stiber, J.A., Rosenberg, P.B., Premont, R.T., Coffman, T.M., Rockman, H.A., Lefkowitz, R.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes. Hupfeld, C.J., Dalle, S., Olefsky, J.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  4. beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Kohout, T.A., Lin, F.S., Perry, S.J., Conner, D.A., Lefkowitz, R.J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  5. Beta-arrestin mediates desensitization and internalization but does not affect dephosphorylation of the thyrotropin-releasing hormone receptor. Jones, B.W., Hinkle, P.M. J. Biol. Chem. (2005) [Pubmed]
  6. Palmitoylation of the 5-hydroxytryptamine4a receptor regulates receptor phosphorylation, desensitization, and beta-arrestin-mediated endocytosis. Ponimaskin, E., Dumuis, A., Gaven, F., Barthet, G., Heine, M., Glebov, K., Richter, D.W., Oppermann, M. Mol. Pharmacol. (2005) [Pubmed]
  7. Genetic mapping of the beta-arrestin 1 and 2 genes on mouse chromosomes 7 and 11 respectively. Kingsmore, S.F., Peppel, K., Suh, D., Caron, M.G., Lefkowitz, R.J., Seldin, M.F. Mamm. Genome (1995) [Pubmed]
  8. The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors. Teo, M., Tan, L., Lim, L., Manser, E. J. Biol. Chem. (2001) [Pubmed]
  9. Agonist mediated internalization of M2 mAChR is beta-arrestin-dependent. Jones, K.T., Echeverry, M., Mosser, V.A., Gates, A., Jackson, D.A. Journal of molecular signaling (2006) [Pubmed]
  10. An opioid agonist that does not induce micro-opioid receptor--arrestin interactions or receptor internalization. Groer, C.E., Tidgewell, K., Moyer, R.A., Harding, W.W., Rothman, R.B., Prisinzano, T.E., Bohn, L.M. Mol. Pharmacol. (2007) [Pubmed]
  11. Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin. Roy, D., Angelini, N.L., Fujieda, H., Brown, G.M., Belsham, D.D. Endocrinology (2001) [Pubmed]
  12. beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport. Imamura, T., Huang, J., Dalle, S., Ugi, S., Usui, I., Luttrell, L.M., Miller, W.E., Lefkowitz, R.J., Olefsky, J.M. J. Biol. Chem. (2001) [Pubmed]
  13. Protease-activated receptor-2 simultaneously directs beta-arrestin-1-dependent inhibition and Galphaq-dependent activation of phosphatidylinositol 3-kinase. Wang, P., DeFea, K.A. Biochemistry (2006) [Pubmed]
  14. G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse: psychostimulant and opiate studies in knockout mice. Bohn, L.M., Gainetdinov, R.R., Caron, M.G. Neuromolecular Med. (2004) [Pubmed]
  15. Agonist activated adrenocorticotropin receptor internalizes via a clathrin-mediated G protein receptor kinase dependent mechanism. Baig, A.H., Swords, F.M., Szaszák, M., King, P.J., Hunyady, L., Clark, A.J. Endocr. Res. (2002) [Pubmed]
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