The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Scnn1g  -  sodium channel, nonvoltage-gated 1 gamma

Mus musculus

Synonyms: Amiloride-sensitive sodium channel subunit gamma, ENaC gamma, Epithelial Na(+) channel subunit gamma, Gamma-ENaC, Gamma-NaCH, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Scnn1g

 

Biological context of Scnn1g

 

Anatomical context of Scnn1g

 

Associations of Scnn1g with chemical compounds

  • In contrast, alpha-ENaC was markedly upregulated, and the molecular weight of a large fraction of gamma-ENaC subunits was shifted from 85 to 70 kD, consistent with previous results from rat models with elevated plasma aldosterone levels [8].
  • Dex increased beta- and gamma-ENaC in lung, but only after >48 h of exposure, and had no effect on kidney [9].
 

Regulatory relationships of Scnn1g

 

Other interactions of Scnn1g

  • As in the AQP1 knockout mice, ClC-nK1 (-/-) mice showed decreased expression of UT-A1 and increased expression of beta-ENaC and gamma-ENaC vs. WT controls [11].
  • In contrast, there was increased expression of three proteins normally expressed at higher levels in the cortical collecting duct (CCD) than in IMCD: AQP3 (another basolateral water channel) and the epithelial sodium channel subunits beta-ENaC and gamma-ENaC [11].
 

Analytical, diagnostic and therapeutic context of Scnn1g

References

  1. Phosphatidylinositol 3,4,5-trisphosphate mediates aldosterone stimulation of epithelial sodium channel (ENaC) and interacts with gamma-ENaC. Helms, M.N., Liu, L., Liang, Y.Y., Al-Khalili, O., Vandewalle, A., Saxena, S., Eaton, D.C., Ma, H.P. J. Biol. Chem. (2005) [Pubmed]
  2. Ikappab kinase-beta (ikkbeta) modulation of epithelial sodium channel activity. Lebowitz, J., Edinger, R.S., An, B., Perry, C.J., Onate, S., Kleyman, T.R., Johnson, J.P. J. Biol. Chem. (2004) [Pubmed]
  3. Roles of the C termini of alpha -, beta -, and gamma -subunits of epithelial Na+ channels (ENaC) in regulating ENaC and mediating its inhibition by cytosolic Na+. Dinudom, A., Harvey, K.F., Komwatana, P., Jolliffe, C.N., Young, J.A., Kumar, S., Cook, D.I. J. Biol. Chem. (2001) [Pubmed]
  4. Epithelial sodium channel genes Scnn1b and Scnn1g are closely linked on distal mouse chromosome 7. Brooker, D.R., Kozak, C.A., Kleyman, T.R. Genomics (1995) [Pubmed]
  5. Subunits of the epithelial sodium channel family are differentially expressed in the retina of mice with ocular hypertension. Dyka, F.M., May, C.A., Enz, R. J. Neurochem. (2005) [Pubmed]
  6. Differential subcellular localization of ENaC subunits in mouse kidney in response to high- and low-Na diets. Loffing, J., Pietri, L., Aregger, F., Bloch-Faure, M., Ziegler, U., Meneton, P., Rossier, B.C., Kaissling, B. Am. J. Physiol. Renal Physiol. (2000) [Pubmed]
  7. PKA-dependent ENaC trafficking requires the SNARE-binding protein complexin. Butterworth, M.B., Frizzell, R.A., Johnson, J.P., Peters, K.W., Edinger, R.S. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  8. Pendrin regulation in mouse kidney primarily is chloride-dependent. Vallet, M., Picard, N., Loffing-Cueni, D., Fysekidis, M., Bloch-Faure, M., Deschênes, G., Breton, S., Meneton, P., Loffing, J., Aronson, P.S., Chambrey, R., Eladari, D. J. Am. Soc. Nephrol. (2006) [Pubmed]
  9. Endogenous and exogenous glucocorticoid regulation of ENaC mRNA expression in developing kidney and lung. Nakamura, K., Stokes, J.B., McCray, P.B. Am. J. Physiol., Cell Physiol. (2002) [Pubmed]
  10. Modulation of alpha-ENaC and alpha1-Na+-K+-ATPase by cAMP and dexamethasone in alveolar epithelial cells. Dagenais, A., Denis, C., Vives, M.F., Girouard, S., Massé, C., Nguyen, T., Yamagata, T., Grygorczyk, C., Kothary, R., Berthiaume, Y. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  11. Altered expression profile of transporters in the inner medullary collecting duct of aquaporin-1 knockout mice. Morris, R.G., Uchida, S., Brooks, H., Knepper, M.A., Chou, C.L. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
 
WikiGenes - Universities