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Gene Review

gpn-1  -  Protein GPN-1

Caenorhabditis elegans

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Disease relevance of glypican


High impact information on glypican

  • LON-2 is a conserved member of the glypican family of heparan sulfate proteoglycans, a family with several members known to regulate growth-factor signaling in many organisms [2].


  1. C. elegans Kallmann syndrome protein KAL-1 interacts with syndecan and glypican to regulate neuronal cell migrations. Hudson, M.L., Kinnunen, T., Cinar, H.N., Chisholm, A.D. Dev. Biol. (2006) [Pubmed]
  2. Glypican LON-2 Is a Conserved Negative Regulator of BMP-like Signaling in Caenorhabditis elegans. Gumienny, T.L., Macneil, L.T., Wang, H., de Bono, M., Wrana, J.L., Padgett, R.W. Curr. Biol. (2007) [Pubmed]
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