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Gene Review

dlp  -  dally-like

Drosophila melanogaster

Synonyms: CG17703, CG32146, CG5031, CT16138, D-gpcB, ...
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High impact information on dlp


Biological context of dlp


Anatomical context of dlp

  • The Drosophila genes dally and dally-like encode glypicans, which are heparan sulphate proteoglycans anchored to the cell membrane by a glycosylphosphatidylinositol link [4].
  • Genetic analysis of dally-like in wing imaginal discs leads us to a model whereby, at the surface of any given cell of the epithelium, Dally-like captures Wingless but instead of presenting it to signalling receptors expressed in this cell, it passes it on to neighbouring cells, either for paracrine signalling or for further transport [3].

Associations of dlp with chemical compounds

  • The two glypicans Dally and Dally-like have been implicated in modulating the activity of Wingless, a member of the Wnt family of secreted glycoprotein [3].
  • The heparan sulfate proteoglycans Dally-like and Syndecan have distinct functions in axon guidance and visual-system assembly in Drosophila [7].
  • Because earlier work indicated that extracts of delayed-recovery flies could occasionally transmit CO2 sensitivity when injected into resistant recipients, we have tested the possibility that some delayed-recovery stocks contain a sigma-like transmissible virus, in addition to the Dly gene [6].

Physical interactions of dlp

  • Thus, spatially regulated modification of Dlp by Notum employs the ligand binding activity of Dlp to promote or inhibit signaling in a context-dependent manner [8].

Regulatory relationships of dlp

  • Several lines of evidence implicate heparan sulfate-modified proteoglycans (HSPGs) such as Dally-like protein (Dlp) in the control of Wg distribution and signaling [9].
  • Notum-induced shedding of Dlp could convert Dlp from a membrane-tethered coreceptor to a secreted antagonist [8].

Other interactions of dlp

  • The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis of Drosophila [4].
  • Epistatic experiments show that Dally-like is required for the reception of the Hedgehog signal, upstream or at the level of the Patched receptor [4].
  • In addition, we also studied the expression patterns of two genes with similarity to Drosophila frizzled, T23D8.1 and F27E11.3A, and the ortholog of the Drosophila gene dally-like, gpn-1, which is a heparan sulfate proteoglycan [10].


  1. The HSPGs Syndecan and Dallylike bind the receptor phosphatase LAR and exert distinct effects on synaptic development. Johnson, K.G., Tenney, A.P., Ghose, A., Duckworth, A.M., Higashi, M.E., Parfitt, K., Marcu, O., Heslip, T.R., Marsh, J.L., Schwarz, T.L., Flanagan, J.G., Van Vactor, D. Neuron (2006) [Pubmed]
  2. Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc. Han, C., Yan, D., Belenkaya, T.Y., Lin, X. Development (2005) [Pubmed]
  3. Glypicans shunt the Wingless signal between local signalling and further transport. Franch-Marro, X., Marchand, O., Piddini, E., Ricardo, S., Alexandre, C., Vincent, J.P. Development (2005) [Pubmed]
  4. The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis of Drosophila. Desbordes, S.C., Sanson, B. Development (2003) [Pubmed]
  5. Syndecan-dependent binding of Drosophila hemocytes to laminin alpha3/5 chain LG4-5 modules: potential role in sessile hemocyte islets formation. Narita, R., Yamashita, H., Goto, A., Imai, H., Ichihara, S., Mori, H., Kitagawa, Y. FEBS Lett. (2004) [Pubmed]
  6. Independent production of CO2 sensitivity by nuclear gene Dly and a transmissible agent from delayed-recovery Drosophila melanogaster. Clark, M.A., McCrady, W.B., Fielding, C.L. Genetics (1979) [Pubmed]
  7. The heparan sulfate proteoglycans Dally-like and Syndecan have distinct functions in axon guidance and visual-system assembly in Drosophila. Rawson, J.M., Dimitroff, B., Johnson, K.G., Rawson, J.M., Ge, X., Van Vactor, D., Selleck, S.B. Curr. Biol. (2005) [Pubmed]
  8. Opposing activities of Dally-like glypican at high and low levels of Wingless morphogen activity. Kreuger, J., Perez, L., Giraldez, A.J., Cohen, S.M. Dev. Cell (2004) [Pubmed]
  9. Spatial regulation of Wingless morphogen distribution and signaling by Dally-like protein. Kirkpatrick, C.A., Dimitroff, B.D., Rawson, J.M., Selleck, S.B. Dev. Cell (2004) [Pubmed]
  10. Comprehensive analysis of gene expression patterns of hedgehog-related genes. Hao, L., Johnsen, R., Lauter, G., Baillie, D., B??rglin, T.R. BMC Genomics (2006) [Pubmed]
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