The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Kallmann Syndrome

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Kallmann Syndrome


High impact information on Kallmann Syndrome


Chemical compound and disease context of Kallmann Syndrome


Biological context of Kallmann Syndrome


Anatomical context of Kallmann Syndrome

  • X-linked Kallmann syndrome (X-KS), characterized by failed gonadal function secondary to deficient gonadotropin secretion, is caused by a mutation in KAL1, which is suggested to regulate the migration of forebrain GnRH neurons [19].

Gene context of Kallmann Syndrome


  1. Ontogeny of GnRH and olfactory neuronal systems in man: novel insights from the investigation of inherited forms of Kallmann's syndrome. González-Martínez, D., Hu, Y., Bouloux, P.M. Frontiers in neuroendocrinology. (2004) [Pubmed]
  2. The product of X-linked Kallmann's syndrome gene (KAL1) affects the migratory activity of gonadotropin-releasing hormone (GnRH)-producing neurons. Cariboni, A., Pimpinelli, F., Colamarino, S., Zaninetti, R., Piccolella, M., Rumio, C., Piva, F., Rugarli, E.I., Maggi, R. Hum. Mol. Genet. (2004) [Pubmed]
  3. Hormonal therapy of male hypogonadism. Matsumoto, A.M. Endocrinol. Metab. Clin. North Am. (1994) [Pubmed]
  4. Pulsatile gonadotropin-releasing hormone therapy in male patients with Kallmann's syndrome or constitutional delay of puberty. Happ, J., Ditscheid, W., Krause, U. Fertil. Steril. (1985) [Pubmed]
  5. Anosmin-1, defective in the X-linked form of Kallmann syndrome, promotes axonal branch formation from olfactory bulb output neurons. Soussi-Yanicostas, N., de Castro, F., Julliard, A.K., Perfettini, I., Chédotal, A., Petit, C. Cell (2002) [Pubmed]
  6. Brief report: intragenic deletion of the KALIG-1 gene in Kallmann's syndrome. Bick, D., Franco, B., Sherins, R.J., Heye, B., Pike, L., Crawford, J., Maddalena, A., Incerti, B., Pragliola, A., Meitinger, T. N. Engl. J. Med. (1992) [Pubmed]
  7. Kallmann's syndrome associated with atrial septal defect. Dimitrovski, C., Plaseski, A., Bogoev, M., Sadikario, S. JAMA (1982) [Pubmed]
  8. The gene for X-linked Kallmann syndrome: a human neuronal migration defect. Ballabio, A., Camerino, G. Curr. Opin. Genet. Dev. (1992) [Pubmed]
  9. Altered osmotic threshold for vasopressin release and impaired thirst sensation: additional abnormalities in Kallmann's syndrome. Hochberg, Z., Moses, A.M., Miller, M., Benderli, A., Richman, R.A. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  10. Elevated nocturnal melatonin is a consequence of gonadotropin-releasing hormone deficiency in women with hypothalamic amenorrhea. Kadva, A., Djahanbakhch, O., Monson, J., Di, W.L., Silman, R. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  11. Dissociation of prolactin responsiveness to thyrotropin-releasing hormone and chlorpromazine in a female with Kallmann's syndrome. Turksoy, R.N. Fertil. Steril. (1979) [Pubmed]
  12. L-hydroxytryptophan amplifies pulsatile secretion of LH in the follicular phase of normal women. Lado-Abeal, J., Rey, C., Cabezas-Agricola, J.M., Rodriguez, A., Camarero, E., Cabezas-Cerrato, J. Clin. Endocrinol. (Oxf) (1997) [Pubmed]
  13. The predictive value of double Gn-RH provocation test in unprimed Gn-RH-primed and steroid-primed female patients with Kallmann's syndrome. Chryssikopoulos, A., Gregoriou, O., Vitoratos, N., Rizos, D., Papadias, K. International journal of fertility and women's medicine. (1998) [Pubmed]
  14. Initial characterization of anosmin-1, a putative extracellular matrix protein synthesized by definite neuronal cell populations in the central nervous system. Soussi-Yanicostas, N., Hardelin, J.P., Arroyo-Jimenez, M.M., Ardouin, O., Legouis, R., Levilliers, J., Traincard, F., Betton, J.M., Cabanié, L., Petit, C. J. Cell. Sci. (1996) [Pubmed]
  15. A recurrent missense mutation in the KAL gene in patients with X-linked Kallmann's syndrome. Maya-Nuñez, G., Zenteno, J.C., Ulloa-Aguirre, A., Kofman-Alfaro, S., Mendez, J.P. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  16. Osmoregulation of thirst and vasopressin secretion in Kallmann's syndrome. Thompson, C.J., White, M.C., Baylis, P.H. Clin. Endocrinol. (Oxf) (1989) [Pubmed]
  17. Successful induction ovulation and completed pregnancy using recombinant human luteinizing hormone and follicle stimulating hormone in a woman with Kallmann's syndrome. Kousta, E., White, D.M., Piazzi, A., Loumaye, E., Franks, S. Hum. Reprod. (1996) [Pubmed]
  18. Investigation of a unique male and female sibship with Kallmann's syndrome and 46,XX gonadal dysgenesis with short stature. Persson, J.W., Humphrey, K., Watson, C., Taylor, P., Leigh, D., McDonald, B., Fraser, I.S. Hum. Reprod. (1999) [Pubmed]
  19. Forebrain gonadotropin-releasing hormone neuronal development: insights from transgenic medaka and the relevance to X-linked Kallmann syndrome. Okubo, K., Sakai, F., Lau, E.L., Yoshizaki, G., Takeuchi, Y., Naruse, K., Aida, K., Nagahama, Y. Endocrinology (2006) [Pubmed]
  20. Mutation analysis of the EMX2 gene in Kallmann's syndrome. Taylor, H.S., Block, K., Bick, D.P., Sherins, R.J., Layman, L.C., Shering, R.J. Fertil. Steril. (1999) [Pubmed]
  21. The effect of endogenous and exogenous gonadotrophin-releasing hormone on the prolactin response to TRH. Gooren, L.J., Van der Veen, E.A., Van Kessel, H., Harmsen-Louman, W. Clin. Endocrinol. (Oxf) (1984) [Pubmed]
  22. Cross-talk of anosmin-1, the protein implicated in X-linked Kallmann's syndrome, with heparan sulphate and urokinase-type plasminogen activator. Hu, Y., González-Martínez, D., Kim, S.H., Bouloux, P.M. Biochem. J. (2004) [Pubmed]
  23. Patterns of pulsatile luteinizing hormone and follicle-stimulating hormone secretion in prepubertal (midchildhood) boys and girls and patients with idiopathic hypogonadotropic hypogonadism (Kallmann's syndrome): a study using an ultrasensitive time-resolved immunofluorometric assay. Wu, F.C., Butler, G.E., Kelnar, C.J., Stirling, H.F., Huhtaniemi, I. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  24. Unconjugated estriol as an indication for prenatal diagnosis of steroid sulfatase deficiency by in situ hybridization. Ahmed, M.N., Killam, A., Thompson, K.H., Qumsiyeh, M.B. Obstetrics and gynecology. (1998) [Pubmed]
WikiGenes - Universities