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Gene Review

Gpc4  -  glypican 4

Mus musculus

Synonyms: 9530073D23Rik, AF311610, AI385680, AI661372, Glypican-4, ...
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High impact information on Gpc4


Biological context of Gpc4


Anatomical context of Gpc4

  • Gpc4 is expressed in adipocytes where its expression is highest in confluent 3T3-F442A adipoblasts and decreases dramatically as cells differentiate [5].

Other interactions of Gpc4

  • Mice carrying the high-growth QTL allele have approximately 15% lower Gpc3 mRNA expression in kidney and liver, whereas expression differences at Gpc4 are non-significant [8].


  1. Hepatocyte growth factor-mediated renal epithelial branching morphogenesis is regulated by glypican-4 expression. Karihaloo, A., Kale, S., Rosenblum, N.D., Cantley, L.G. Mol. Cell. Biol. (2004) [Pubmed]
  2. Glypican 4 modulates FGF signalling and regulates dorsoventral forebrain patterning in Xenopus embryos. Galli, A., Roure, A., Zeller, R., Dono, R. Development (2003) [Pubmed]
  3. Expression pattern of glypican-4 suggests multiple roles during mouse development. Ybot-Gonzalez, P., Copp, A.J., Greene, N.D. Dev. Dyn. (2005) [Pubmed]
  4. Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development. Ford-Perriss, M., Turner, K., Guimond, S., Apedaile, A., Haubeck, H.D., Turnbull, J., Murphy, M. Dev. Dyn. (2003) [Pubmed]
  5. Murine glypican-4 gene structure and expression; Sp1 and Sp3 play a major role in glypican-4 expression in 3T3-F442A cells. Li, H., Melford, K., Judson, A., Bensadoun, A. Biochim. Biophys. Acta (2004) [Pubmed]
  6. Mouse K-glypican gene, gpc4, maps to chromosome X. Matsuki, Y., Kaname, T., Suematsu, S., Yamaguchi, Y., Abe, K., Yamamura, K. Genomics (1998) [Pubmed]
  7. Mechanical strain regulation of the chicken glypican-4 gene expression in the avian eggshell gland. Lavelin, I., Meiri, N., Einat, M., Genina, O., Pines, M. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2002) [Pubmed]
  8. Regulatory variation at glypican-3 underlies a major growth QTL in mice. Oliver, F., Christians, J.K., Liu, X., Rhind, S., Verma, V., Davison, C., Brown, S.D., Denny, P., Keightley, P.D. PLoS Biol. (2005) [Pubmed]
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