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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SOD2  -  superoxide dismutase 2, mitochondrial

Bos taurus

 
 
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High impact information on SOD2

  • Of the other two sequenced amplicons, one encoded a partial sequence for mitochondrial manganese-dependent superoxide dismutase (SOD2), an enzyme that is likely to protect adrenocortical cells from the cytotoxic effects of radical oxygen species generated during steroid biosynthesis [1].
  • Identification of two novel ACTH-responsive genes encoding manganese-dependent superoxide dismutase (SOD2) and the zinc finger protein TIS11b [tetradecanoyl phorbol acetate (TPA)-inducible sequence 11b] [1].
  • SOD2 induction by ACTH was independent of extracellular steroid concentration or oxidative stress [1].
  • In 32D cl 3 hematopoietic progenitor cells, the overexpression of manganese superoxide dismutase (MnSOD, SOD2), the enzyme normally found in mitochondria, protects against the damaging effects of ionizing radiation [2].

References

  1. Identification of two novel ACTH-responsive genes encoding manganese-dependent superoxide dismutase (SOD2) and the zinc finger protein TIS11b [tetradecanoyl phorbol acetate (TPA)-inducible sequence 11b]. Chinn, A.M., Ciais, D., Bailly, S., Chambaz, E., LaMarre, J., Feige, J.J. Mol. Endocrinol. (2002) [Pubmed]
  2. Identification of respiratory complexes I and III as mitochondrial sites of damage following exposure to ionizing radiation and nitric oxide. Pearce, L.L., Epperly, M.W., Greenberger, J.S., Pitt, B.R., Peterson, J. Nitric Oxide (2001) [Pubmed]
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