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Gene Review:

Olfr7 - olfactory receptor 7 complex

Mus musculus

Synonyms: M71, MOR171-2

Li, J. et al., Potter, S.M. et al., Bozza, T. et al., Vassalli, A. et al.

Vassalli, Rothman, Feinstein, Zapotocky, Mombaerts,

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High impact information on Olfr7

Both processes are here recapitulated by MOR23 and M71 OR minigenes, introduced into mice [1].
OSNs that differentiate from ntES cells after injection into blastocysts are not restricted to expression of M71 but can express other OR genes [2].
Using M71-expressing OSNs as donors for nuclear transfer, we generate blastocysts, embryonic stem (ntES) cell lines and clonal mice [2].
DNA analysis of these cell lines, whose genome is clonally derived from an M71-expressing OSN, does not reveal DNA rearrangements or sequence alterations at the M71 locus [2].
We show that the odorants acetophenone and benzaldehyde are agonists for the M71 OR and that M71-expressing neurons are functionally similar in their response properties across concentration [3].

Other interactions of Olfr7

We have constructed by gene targeting novel strains of mice in which either all OSNs or those that express a specific OR gene, M72 or M71, also produce green fluorescent protein (GFP) or a fusion of tau with GFP [4].

References

Minigenes impart odorant receptor-specific axon guidance in the olfactory bulb. Vassalli, A., Rothman, A., Feinstein, P., Zapotocky, M., Mombaerts, P. Neuron (2002) [Pubmed]
Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons. Li, J., Ishii, T., Feinstein, P., Mombaerts, P. Nature (2004) [Pubmed]
Odorant receptor expression defines functional units in the mouse olfactory system. Bozza, T., Feinstein, P., Zheng, C., Mombaerts, P. J. Neurosci. (2002) [Pubmed]
Structure and emergence of specific olfactory glomeruli in the mouse. Potter, S.M., Zheng, C., Koos, D.S., Feinstein, P., Fraser, S.E., Mombaerts, P. J. Neurosci. (2001) [Pubmed]

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