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Gene Review

DUSP9  -  dual specificity phosphatase 9

Homo sapiens

Synonyms: Dual specificity protein phosphatase 9, MAP kinase phosphatase 4, MKP-4, MKP4, Mitogen-activated protein kinase phosphatase 4
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Disease relevance of DUSP9


High impact information on DUSP9

  • Northern analysis reveals a highly restricted tissue distribution with a single MKP-4 mRNA species of approximately 2.5 kilobases detected only in placenta, kidney, and embryonic liver [1].
  • Immunocytochemical analysis showed MKP-4 to be present within cytosol although punctate nuclear staining co-localizing with promyelocytic protein was also observed in a subpopulation (10-20%) of cells [1].
  • Chromosomal localization by analysis of DNAs from human/rodent somatic cell hybrids and a panel of radiation hybrids assign the human gene for MKP-4 to Xq28 [1].
  • By searching the expressed sequence tag data base (dbEST) for homologues of known dual specificity phosphatases, we identified a novel partial human sequence for which we isolated a full-length cDNA (termed MKP-4) [1].
  • MKP-4 and MKP-5 were uniformly absent [3].

Associations of DUSP9 with chemical compounds

  • Both MKP-4 and the MKP-4/p38 complex exhibited moderate activity toward the surrogate substrates p-nitrophenyl phosphate, 6, 8-difluoro-4-methylumbelliferyl phosphate, and 3-O-methylfluorescein phosphate [2].

Other interactions of DUSP9


Analytical, diagnostic and therapeutic context of DUSP9


  1. Molecular cloning and functional characterization of a novel mitogen-activated protein kinase phosphatase, MKP-4. Muda, M., Boschert, U., Smith, A., Antonsson, B., Gillieron, C., Chabert, C., Camps, M., Martinou, I., Ashworth, A., Arkinstall, S. J. Biol. Chem. (1997) [Pubmed]
  2. Expression, purification, and enzymatic characterization of the dual specificity mitogen-activated protein kinase phosphatase, MKP-4. Hong, S.B., Lubben, T.H., Dolliver, C.M., Petrolonis, A.J., Roy, R.A., Li, Z., Parsons, T.F., Li, P., Xu, H., Reilly, R.M., Trevillyan, J.M., Nichols, A.J., Tummino, P.J., Gant, T.G. Bioorg. Chem. (2005) [Pubmed]
  3. The PAC-1 dual specificity phosphatase predicts poor outcome in serous ovarian carcinoma. Givant-Horwitz, V., Davidson, B., Goderstad, J.M., Nesland, J.M., Tropé, C.G., Reich, R. Gynecol. Oncol. (2004) [Pubmed]
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