Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Y45G12C.10 - Protein Y45G12C.10

Caenorhabditis elegans

van der Linden, A.M. et al., Bergamasco, C. et al., Singaravelu, G. et al.

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High impact information on chemoreceptor

A calcineurin phosphatase antagonizes the KIN-29/MEF-2-regulated pathway to modulate levels of CR gene expression [1].
MEF-2 binds directly to the CR gene regulatory sequences, and is required only to repress but not activate CR gene expression [1].
An unusual feature, possibly due to C. elegans's strong dependence on chemical cues, is the very large number of GPCR chemoreceptor genes (1300-1700) coded in its genome [2].
Here we describe specific genetic interaction between tax-6 and kin-29 in regulating body size, serotonin mediated egg laying, and chemoreceptor expression [3].

References

KIN-29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC. van der Linden, A.M., Nolan, K.M., Sengupta, P. EMBO J. (2007) [Pubmed]
Chemical sensitivity in Caenorhabditis elegans. Bergamasco, C., Bazzicalupo, P. Cell. Mol. Life Sci. (2006) [Pubmed]
Calcineurin interacts with KIN-29, a Ser/Thr kinase, in Caenorhabditis elegans. Singaravelu, G., Song, H.O., Ji, Y.J., Jee, C., Park, B.J., Ahnn, J. Biochem. Biophys. Res. Commun. (2007) [Pubmed]

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