Disease relevance of cir

• Auditory test results identified clearly the hearing loss of the cir, compared with wild-type mice [1].
• Pathologic studies confirmed developmental defects in cochlea and spiral ganglions that were correlated to the abnormal behavior observed in the cir mice [1].

High impact information on cir

• In addition, all three proteins are required for l-norepinephrine-facilitated iron uptake from transferrin as judged by failure of a fepA iroN cir triple mutant to grow in serum-containing medium in the presence of l-norepinephrine [2].
• The cir mouse is defective in Tmie gene, the function of which should be further elucidated [3].
• OBJECTIVES: We previously reported a recessive mutation of deafness called circling mice (cir/cir) [3].
• Fine mapping of the circling (cir) gene on the distal portion of mouse chromosome 9 [4].
• On the basis of genetic mapping, we constructed a yeast artificial chromosome (YAC) contig across the cir region [4].

Biological context of cir

• A genetic linkage map was constructed for an intraspecific backcross between cir and C57BL/6J mice [4].
• The mutation was inherited by an autosomal single recessive gene and is referred to as cir [5].
• CONCLUSION: The circling mouse (cir/cir) has phenotypes which follow the pattern of neuroepithelial defects of deafness from 10 days after birth [3].

Anatomical context of cir

• Thus, cir mice may be useful as a model for studying inner ear abnormalities and deafness in humans [1].

Associations of cir with chemical compounds

• Moreover, pre-treatment of mice with l-norepinephrine resulted in enhanced systemic spread of the parental strain, but had no effect on the fepA iroN cir mutant [2].

References