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Gene Review

Socs7  -  suppressor of cytokine signaling 7

Mus musculus

Synonyms: 2310063P06Rik, C85125, Cish7, Nap4, SOCS-7, ...
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Disease relevance of Socs7


High impact information on Socs7


Associations of Socs7 with chemical compounds

  • We investigated the binding specificity of the SOCS-6 and SOCS-7 SH2 domains and found that they preferentially bound to phosphopeptides containing a valine in the phosphotyrosine (pY) +1 position and a hydrophobic residue in the pY +2 and pY +3 positions [3].

Analytical, diagnostic and therapeutic context of Socs7


  1. Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans. Banks, A.S., Li, J., McKeag, L., Hribal, M.L., Kashiwada, M., Accili, D., Rothman, P.B. J. Clin. Invest. (2005) [Pubmed]
  2. Development of hydrocephalus in mice lacking SOCS7. Krebs, D.L., Metcalf, D., Merson, T.D., Voss, A.K., Thomas, T., Zhang, J.G., Rakar, S., O'bryan, M.K., Willson, T.A., Viney, E.M., Mielke, L.A., Nicola, N.A., Hilton, D.J., Alexander, W.S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation. Krebs, D.L., Uren, R.T., Metcalf, D., Rakar, S., Zhang, J.G., Starr, R., De Souza, D.P., Hanzinikolas, K., Eyles, J., Connolly, L.M., Simpson, R.J., Nicola, N.A., Nicholson, S.E., Baca, M., Hilton, D.J., Alexander, W.S. Mol. Cell. Biol. (2002) [Pubmed]
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