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Gene Review

SOCS7  -  suppressor of cytokine signaling 7

Homo sapiens

Synonyms: NAP-4, NAP4, NCKAP4, Nck, Ash and phospholipase C gamma-binding protein, Nck-associated protein 4, ...
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Disease relevance of SOCS7


High impact information on SOCS7

  • We report here the role of one of the less studied members of the family of suppressors of cytokine signaling (SOCS), namely SOCS-7, in cytokine signaling [2].
  • We identified the cytoskeletal molecule vinexin as a partner interacting with SOCS-7 [3].
  • To understand the function of the suppressor of cytokine signaling (SOCS)-7, we have looked for proteins interacting with SOCS-7 in a stringent yeast two-hybrid screen of a human leukocyte cDNA-library [3].
  • Tests with deletion mutants of SOCS-7 demonstrated that a central region of the molecule containing several proline-rich regions, N-terminal to the SH2 domain, was responsible for the binding to vinexin [3].
  • Nitrate consumption, along with the results from the (14)C radiolabel study, are consistent with the oxidation of naphthalene coupled to denitrification for NAP-3-1 and nitrate reduction to nitrite for NAP-4 [1].

Biological context of SOCS7


Anatomical context of SOCS7


Associations of SOCS7 with chemical compounds

  • Three naphthalene-degrading pure cultures were obtained, designated NAP-3-1, NAP-3-2, and NAP-4 [1].

Other interactions of SOCS7


  1. Anaerobic naphthalene degradation by microbial pure cultures under nitrate-reducing conditions. Rockne, K.J., Chee-Sanford, J.C., Sanford, R.A., Hedlund, B.P., Staley, J.T., Strand, S.E. Appl. Environ. Microbiol. (2000) [Pubmed]
  2. Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. Martens, N., Uzan, G., Wery, M., Hooghe, R., Hooghe-Peters, E.L., Gertler, A. J. Biol. Chem. (2005) [Pubmed]
  3. The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin. Martens, N., Wery, M., Wang, P., Braet, F., Gertler, A., Hooghe, R., Vandenhaute, J., Hooghe-Peters, E.L. Exp. Cell Res. (2004) [Pubmed]
  4. Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via Pkcdelta activation. Hwang, M.N., Ha, T.H., Park, J., Shim, J., Lee, H., Kim, Y.N., Lee, E.S., Yoon, S. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  5. Identification of a novel platelet-derived neutrophil-chemotactic polypeptide with structural homology to platelet-factor 4. Schröder, J.M., Sticherling, M., Persoon, N.L., Christophers, E. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  6. The human cumulus--oocyte complex gene-expression profile. Assou, S., Anahory, T., Pantesco, V., Le Carrour, T., Pellestor, F., Klein, B., Reyftmann, L., Dechaud, H., De Vos, J., Hamamah, S. Hum. Reprod. (2006) [Pubmed]
  7. A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs. Matuoka, K., Miki, H., Takahashi, K., Takenawa, T. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
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