The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Fzd8  -  frizzled homolog 8 (Drosophila)

Mus musculus

Synonyms: Frizzled-8, Fz-8, Fz8, mFZ8, mFz8
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Fzd8

 

Biological context of Fzd8

  • Two Asn-linked glycosylation sites within the N-terminal extracellular region were conserved among vertebrate Fzd8 orhologs [3].
  • Nucleotide position 92950-94221 of AC131883.2 genome sequence was identified as the evolutionarily conserved promoter region of rat Fzd8 gene, and nucleotide position 133421-132134 of AL121749.14 genome sequence as the evolutionarily conserved promoter region of human FZD8 gene [3].
 

Associations of Fzd8 with chemical compounds

 

Analytical, diagnostic and therapeutic context of Fzd8

  • RT-PCR showed that Fz receptors, Fz1-Fz8 are expressed in lens [4].

References

  1. Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Castelo-Branco, G., Wagner, J., Rodriguez, F.J., Kele, J., Sousa, K., Rawal, N., Pasolli, H.A., Fuchs, E., Kitajewski, J., Arenas, E. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Mouse Cristin/R-spondin Family Proteins Are Novel Ligands for the Frizzled 8 and LRP6 Receptors and Activate beta-Catenin-dependent Gene Expression. Nam, J.S., Turcotte, T.J., Smith, P.F., Choi, S., Yoon, J.K. J. Biol. Chem. (2006) [Pubmed]
  3. Comparative genomics on Fzd8 orthologs. Katoh, Y., Katoh, M. Oncol. Rep. (2005) [Pubmed]
  4. Expression of Frizzleds and secreted frizzled-related proteins (Sfrps) during mammalian lens development. Chen, Y., Stump, R.J., Lovicu, F.J., McAvoy, J.W. Int. J. Dev. Biol. (2004) [Pubmed]
 
WikiGenes - Universities