High impact information on Fzd8

• Moreover, the soluble cysteine-rich domain of Frizzled-8 (a Wnt inhibitor) blocked endogenous Wnts and the effects of Wnt-1 and -5a on proliferation and the acquisition of a DA phenotype in precursor cultures [1].
• Third, Cristin/R-spondin proteins physically interacted with the extracellular domains of the LRP6 and Fzd8 receptors in vivo and in vitro [2].
• Comparative genomics on Fzd8 orthologs [3].
• These facts indicate the molecular evolution of Fzd8 orthologs [3].
• Here we identified and characterized rat Fzd8 gene by using bioinformatics [3].

Biological context of Fzd8

• Two Asn-linked glycosylation sites within the N-terminal extracellular region were conserved among vertebrate Fzd8 orhologs [3].
• Nucleotide position 92950-94221 of AC131883.2 genome sequence was identified as the evolutionarily conserved promoter region of rat Fzd8 gene, and nucleotide position 133421-132134 of AL121749.14 genome sequence as the evolutionarily conserved promoter region of human FZD8 gene [3].

Associations of Fzd8 with chemical compounds

• One Asn-linked glycosylation site within the second extracellular loop was conserved among mammalian Fzd8 orthologs, but not in Xenopus and zebrafish fzd8 orthologs [3].

Analytical, diagnostic and therapeutic context of Fzd8

• RT-PCR showed that Fz receptors, Fz1-Fz8 are expressed in lens [4].

References