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Gene Review

Fzd8  -  frizzled homolog 8 (Drosophila)

Mus musculus

Synonyms: Frizzled-8, Fz-8, Fz8, mFZ8, mFz8
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High impact information on Fzd8


Biological context of Fzd8

  • Two Asn-linked glycosylation sites within the N-terminal extracellular region were conserved among vertebrate Fzd8 orhologs [3].
  • Nucleotide position 92950-94221 of AC131883.2 genome sequence was identified as the evolutionarily conserved promoter region of rat Fzd8 gene, and nucleotide position 133421-132134 of AL121749.14 genome sequence as the evolutionarily conserved promoter region of human FZD8 gene [3].

Associations of Fzd8 with chemical compounds


Analytical, diagnostic and therapeutic context of Fzd8

  • RT-PCR showed that Fz receptors, Fz1-Fz8 are expressed in lens [4].


  1. Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Castelo-Branco, G., Wagner, J., Rodriguez, F.J., Kele, J., Sousa, K., Rawal, N., Pasolli, H.A., Fuchs, E., Kitajewski, J., Arenas, E. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Mouse Cristin/R-spondin Family Proteins Are Novel Ligands for the Frizzled 8 and LRP6 Receptors and Activate beta-Catenin-dependent Gene Expression. Nam, J.S., Turcotte, T.J., Smith, P.F., Choi, S., Yoon, J.K. J. Biol. Chem. (2006) [Pubmed]
  3. Comparative genomics on Fzd8 orthologs. Katoh, Y., Katoh, M. Oncol. Rep. (2005) [Pubmed]
  4. Expression of Frizzleds and secreted frizzled-related proteins (Sfrps) during mammalian lens development. Chen, Y., Stump, R.J., Lovicu, F.J., McAvoy, J.W. Int. J. Dev. Biol. (2004) [Pubmed]
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