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Gene Review

EIF2S3  -  eukaryotic translation initiation factor 2...

Homo sapiens

Synonyms: EIF2, EIF2G, EIF2gamma, Eukaryotic translation initiation factor 2 subunit 3, Eukaryotic translation initiation factor 2 subunit gamma X, ...
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High impact information on EIF2S3

  • This fragment was used as a probe to screen for larger cDNAs and eventually a clone containing the complete eIF-2 gamma coding region (1416 base pairs) was identified [1].
  • Transfection of COS-1 cells with the cDNA results in overexpression of a 52-kDa protein which is specifically recognized by anti-eIF-2 gamma antibodies [1].
  • Eukaryotic initiation factor (eIF)-2 alpha, eIF-2 beta, and eIF-4A each formed a single immunoreactive spot; eIF-2 gamma formed 2 spots; and eIF-4B formed a complex array of 12-20 spots [2].
  • However, when eIF-2 was preincubated specifically with the eIF-2 gamma-subunit antibodies, subsequent co-immunoprecipitation of p67 with the eIF-2 subunits was completely inhibited [3].
  • CTCF binding sites were also present at the 5' end of two other escape genes, mouse Eif2s3x and human EIF2S3, each adjacent to an inactivated gene, but not at genes embedded within large escape domains [4].

Biological context of EIF2S3


  1. Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit. Gaspar, N.J., Kinzy, T.G., Scherer, B.J., Hümbelin, M., Hershey, J.W., Merrick, W.C. J. Biol. Chem. (1994) [Pubmed]
  2. Regulation of initiation factors during translational repression caused by serum depletion. Covalent modification. Duncan, R., Hershey, J.W. J. Biol. Chem. (1985) [Pubmed]
  3. Characteristics of the eukaryotic initiation factor 2 associated 67-kDa polypeptide. Ray, M.K., Chakraborty, A., Datta, B., Chattopadhyay, A., Saha, D., Bose, A., Kinzy, T.G., Wu, S., Hileman, R.E., Merrick, W.C. Biochemistry (1993) [Pubmed]
  4. Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development. Filippova, G.N., Cheng, M.K., Moore, J.M., Truong, J.P., Hu, Y.J., Nguyen, D.K., Tsuchiya, K.D., Disteche, C.M. Dev. Cell (2005) [Pubmed]
  5. Assignment of the eukaryotic translation initiation factor (EIF2S3) to tammar wallaby chromosome 5p by in situ hybridization. Delbridge, M.L., Graves, J.A. Cytogenet. Genome Res. (2004) [Pubmed]
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