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Gene Review

Eif2s3x  -  eukaryotic translation initiation factor 2...

Mus musculus

Synonyms: AA409828, AA547477, AI314668, Eif-2gx, Eukaryotic translation initiation factor 2 subunit 3, X-linked, ...
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High impact information on Eif2s3x

  • Three X-Y gene pairs, Usp9x/y, Ube1x/y and Eif2s3x/y, appeared to be differentially regulated (expressed in brain in a different age- or tissue-dependent pattern), and hence may not be functionally equivalent [1].
  • The effect of a sex difference in Eif2s3x transcription, however, could potentially be offset by the additional expression in male brains of its Y-linked homologue Eif2s3y which was found in similar brain regions [2].
  • The sex difference in Eif2s3x transcript appears not to be preserved at the protein level, since no difference in the levels of Eif2s3 protein was found between (1) males and females (2) XX and XY mice, or (3) XO and XX females [2].
  • Females had significantly higher levels of Eif2s3x mRNA expression than males in cortex, hippocampus and paraventricular nucleus but not in the habenula [2].
  • Gonadally intact XX mice had a higher level of Eif2s3x mRNA expression than XY mice regardless of whether they had testes or ovaries, suggesting that sexually dimorphic gene expression arises as a consequence of sex chromosome complement [2].

Biological context of Eif2s3x

  • Sexually dimorphic expression of the X-linked gene Eif2s3x mRNA but not protein in mouse brain [2].
  • Eif2s3x encodes subunit three of eukaryotic translation initiation factor 2, which regulates the rate of protein translation, and escapes X-inactivation in both humans and mice [2].

Anatomical context of Eif2s3x


Analytical, diagnostic and therapeutic context of Eif2s3x

  • By Northern blot analysis, we found Eif2s3x to be expressed higher in females than in males in developing and adult brains as well as adult liver [2].


  1. Sex differences in sex chromosome gene expression in mouse brain. Xu, J., Burgoyne, P.S., Arnold, A.P. Hum. Mol. Genet. (2002) [Pubmed]
  2. Sexually dimorphic expression of the X-linked gene Eif2s3x mRNA but not protein in mouse brain. Xu, J., Watkins, R., Arnold, A.P. Gene Expr. Patterns (2006) [Pubmed]
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