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Gene Review

eIF-2gamma  -  Eukaryotic initiation factor 2gamma

Drosophila melanogaster

Synonyms: 51kDa protein, CG43665, CG6476, Dmel\CG43665, EIF2-GAMMA, ...
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Disease relevance of Su(var)3-9

  • To analyze the contribution of the N-terminus on the methyltransferase activity, we have expressed the full-length Drosophila SU(VAR)3-9 (dSU(VAR)3-9) together with various N-terminal deletions in Escherichia coli and analyzed the structural and enzymatic properties of the purified recombinant enzymes [1].

High impact information on Su(var)3-9


Biological context of Su(var)3-9


Anatomical context of Su(var)3-9


Associations of Su(var)3-9 with chemical compounds


Physical interactions of Su(var)3-9

  • We suggest a model in which the concerted histone deacetylation and methylation by a SU(VAR)3-9/HDAC1-containing complex leads to a permanent silencing of transcription in particular areas of the genome [13].

Regulatory relationships of Su(var)3-9


Other interactions of Su(var)3-9

  • Together, these data indicate a central role for the SU(VAR)3-9 HMTase in heterochromatin-induced gene silencing in Drosophila [6].
  • The repressive effect of HP1 is decreased by mutation in Su(var)3-9, whose mammalian orthologue encodes a histone H3 methyltransferase and mutation in Su(var)2-1, which is correlated with histone H4 deacetylation [15].
  • The SET domain, first identified within and named after proteins encoded by three Drosophila genes [Su(var)3-9, E(z), and Trithorax], is recognized as a signature motif for histone methyltransferases that are involved in epigenetic processes [16].
  • The distribution of the HP1 and SU(VAR)3-9 proteins depends on the SuUR gene [9].
  • Here we show by immunoaffinity purification that two activities important for chromatin-mediated gene silencing, the histone methyltransferase SU(VAR)3-9 and the histone deacetylase HDAC1, associate in vivo [13].

Analytical, diagnostic and therapeutic context of Su(var)3-9


  1. The N-terminus of Drosophila SU(VAR)3-9 mediates dimerization and regulates its methyltransferase activity. Eskeland, R., Czermin, B., Boeke, J., Bonaldi, T., Regula, J.T., Imhof, A. Biochemistry (2004) [Pubmed]
  2. The chromo and SET domains of the Clr4 protein are essential for silencing in fission yeast. Ivanova, A.V., Bonaduce, M.J., Ivanov, S.V., Klar, A.J. Nat. Genet. (1998) [Pubmed]
  3. The role of histone H2Av variant replacement and histone H4 acetylation in the establishment of Drosophila heterochromatin. Swaminathan, J., Baxter, E.M., Corces, V.G. Genes Dev. (2005) [Pubmed]
  4. Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila. Ebert, A., Schotta, G., Lein, S., Kubicek, S., Krauss, V., Jenuwein, T., Reuter, G. Genes Dev. (2004) [Pubmed]
  5. Distinct HP1 and Su(var)3-9 complexes bind to sets of developmentally coexpressed genes depending on chromosomal location. Greil, F., van der Kraan, I., Delrow, J., Smothers, J.F., de Wit, E., Bussemaker, H.J., van Driel, R., Henikoff, S., van Steensel, B. Genes Dev. (2003) [Pubmed]
  6. Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. Schotta, G., Ebert, A., Krauss, V., Fischer, A., Hoffmann, J., Rea, S., Jenuwein, T., Dorn, R., Reuter, G. EMBO J. (2002) [Pubmed]
  7. SU(VAR)3-9 is a conserved key function in heterochromatic gene silencing. Schotta, G., Ebert, A., Reuter, G. Genetica (2003) [Pubmed]
  8. The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes. Tschiersch, B., Hofmann, A., Krauss, V., Dorn, R., Korge, G., Reuter, G. EMBO J. (1994) [Pubmed]
  9. The SuUR gene influences the distribution of heterochromatic proteins HP1 and SU(VAR)3-9 on nurse cell polytene chromosomes of Drosophila melanogaster. Koryakov, D.E., Reuter, G., Dimitri, P., Zhimulev, I.F. Chromosoma (2006) [Pubmed]
  10. Effects of tethering HP1 to euchromatic regions of the Drosophila genome. Li, Y., Danzer, J.R., Alvarez, P., Belmont, A.S., Wallrath, L.L. Development (2003) [Pubmed]
  11. Intron-regulated expression of SUVH3, an Arabidopsis Su(var)3-9 homologue. Casas-Mollano, J.A., Lao, N.T., Kavanagh, T.A. J. Exp. Bot. (2006) [Pubmed]
  12. Saturation transfer difference measurements with SU(VAR)3-9 and S-adenosyl-L-methionine. Seeger, K., Lein, S., Reuter, G., Berger, S. Biochemistry (2005) [Pubmed]
  13. Physical and functional association of SU(VAR)3-9 and HDAC1 in Drosophila. Czermin, B., Schotta, G., Hülsmann, B.B., Brehm, A., Becker, P.B., Reuter, G., Imhof, A. EMBO Rep. (2001) [Pubmed]
  14. Increased expression of Drosophila Su(var)3-7 triggers Su(var)3-9-dependent heterochromatin formation. Delattre, M., Spierer, A., Jaquet, Y., Spierer, P. J. Cell. Sci. (2004) [Pubmed]
  15. Transcriptional repression of euchromatic genes by Drosophila heterochromatin protein 1 and histone modifiers. Hwang, K.K., Eissenberg, J.C., Worman, H.J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  16. Plants contain a high number of proteins showing sequence similarity to the animal SUV39H family of histone methyltransferases. Zhao, Z., Shen, W.H. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
  17. Gene regulation of Wiskott-Aldrich syndrome protein and the human homolog of the Drosophila Su(var)3-9: WASP and SUV39H1, two adjacent genes at Xp11.23. Hagemann, T.L., Mares, D., Kwan, S. Biochim. Biophys. Acta (2000) [Pubmed]
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