Disease relevance of Macropodidae

• Role of the alternate pathway of dihydrotestosterone formation in virilization of the wolffian ducts of the tammar wallaby, Macropus eugenii [1].
• Adrenal insufficiency and the effects of steroid replacement therapy in the tammar wallaby (Macropus eugenii) [2].
• In common with other marsupials of similar body weights, the red cells of this wallaby were found to have low levels of ATP and higher levels of 2,3-diphosphoglycerate (DPG) and produced no lactate when incubated with inosine [3].
• Oxalate toxicity in a scaly-tailed possum, a Patagonian cavy and a swamp wallaby [4].
• Oxytetracycline, administered at 40 mg kg-1 by intravenous injection, was used as part of the treatment of three female red-necked wallabies, Macropus rufogriseus, with suspected Fusobacterium necrophorum infections [5].

High impact information on Macropodidae

• Although marsupials have been separated from eutherian mammals for approximately 100 million years, homologues of SRY have been localised to the Y chromosome of two unrelated marsupial species, the tammar wallaby and the Darling Downs dunnart [6].
• The region harboring the gene for lysine tRNA (tRNA-Lys) in the mtDNA of other vertebrates is in the wallaroo occupied by a sequence (tRNA-Lys) that lacks both an anticodon loop as well as the anticodon for the amino acid lysine [7].
• The ontogeny of Müllerian inhibiting substance (MIS) production by the developing testis of an Australian marsupial, the tammar wallaby (Macropus eugenii), was determined during pouch life using an organ-culture bioassay of mouse fetal urogenital ridge [8].
• We report here the isolation of WAP from the milk of a marsupial, the tammar wallaby (Macropus eugenii) [9].
• We found that the wallaby has a SWS1 class pigment of 346 amino acids [10].

Chemical compound and disease context of Macropodidae

• Virilization of the male pouch young of the tammar wallaby does not appear to be mediated by plasma testosterone or dihydrotestosterone [11].
• Virilization of the urogenital sinus of the tammar wallaby is not unique to 5alpha-androstane-3alpha,17beta-diol [12].

Biological context of Macropodidae

• Three beta-chain-encoding genes were isolated from a red-necked wallaby (Macropus rufogriseus) cDNA library by using a chimpanzee DRB probe, and their nucleotide sequences were determined [13].
• Here we investigate the molecular evolution of the beta-globin gene family in a marsupial species, the tammar wallaby, Macropus eugenii [14].
• In situ hybridization and Southern blot analysis show that PDHA is autosomal in marsupials, mapping to chromosome 3q in Sminthopsis macroura and 5p in Macropus eugenii [15].
• Cortisol in fetal fluids and the fetal adrenal at parturition in the tammar wallaby (Macropus eugenii) [16].
• Up-regulation of mesotocin receptors in the tammar wallaby myometrium is pregnancy-specific and independent of estrogen [17].

Anatomical context of Macropodidae

• Fluorescent and radioisotope techniques were used sequentially to determine the activity of pathways of glucose metabolism by individual wallaby blastocysts during diapause and 3, 4, 5, 6, 7, 8, and 10 days after removal of pouch young (RPY) [18].
• The organisation presumably underlies the less extensive searching within the developing superior colliculus to generate retinotopic maps in the quokka and also in tammar wallaby [Marotte, J. Comp Neurol. 293:524-539, 1990] than in the rat [Simon and O'Leary, J. Neurosci. 12:1212-1232, 1992] [19].
• Characterization and properties of a progesterone receptor in the uterus of the quokka (Setonix brachyurus) [20].
• Mammary gland lactose concentrations in tammar wallabies are therefore a useful indicator of biosynthetic activity and as an index of lactogenesis but the role, if any, of progesterone withdrawal in lactogenesis remains unclear [21].
• Inhibitors of protein kinase C [1-(5-isoquinolinyl-sulfonyl)-2-methylpiperazine] and phospholipase A2 [dexamethasone] did not effect DiC8-induced acrosomal loss in wallaby spermatozoa [22].

Associations of Macropodidae with chemical compounds

• To investigate the mechanism by which androgens virilize the Wolffian ducts in the tammar wallaby, [(3)H]progesterone was incubated with testes from d 10 and 19 pouch young, and radioactivity was recovered in testosterone and androstanediol at both ages [1].
• Seasonal changes in the circadian plasma melatonin profile of the tammar, Macropus eugenii [23].
• Micropreparative two-dimensional polyacrylamide gel electrophoresis has been used to separate milk whey proteins from the Tammar wallaby (Macropus eugenii) [24].
• The unique feature of the female tammar wallaby is that it does not become a seasonally breeding mammal until after puberty, when it has acquired a corpus luteum [25].
• The data confirm that a local fetal influence is more important than systemic factors, such as estrogen, in the regulation of uterine mesotocin receptors in the tammar wallaby [17].

Gene context of Macropodidae

• We have identified MKRN1 orthologs from human, mouse, wallaby, chicken, fruitfly, and nematode, underscoring the age and conservation of this gene [26].
• Genomic imprinting of IGF2, p57(KIP2) and PEG1/MEST in a marsupial, the tammar wallaby [27].
• The existence of two PGK1 homologous restriction fragments from the X and a large number from the autosomes was also demonstrated by somatic cell hybridization for two other macropodid species, the wallaroo (M. robustus) and the red kangaroo (M. rufus) [28].
• cDNA sequence of the lymphotoxin beta chain from a marsupial, Macropus eugenii (Tammar wallaby) [29].
• Northern analysis of total wallaby liver RNA detected transcripts of 1.8 kb for IGFBP-1 and 1.6 kb for IGFBP-2, the same as those observed in the sheep and rat [30].

Analytical, diagnostic and therapeutic context of Macropodidae

• We describe the expression of EphA3 and EphA7 receptors and ephrin-A2 ligand in the retina and the superior colliculus during the development of the retinocollicular projection in the marsupial wallaby (Macropus eugenii), using immunoblotting and immunohistochemistry [31].
• Oestradiol-17 beta concentrations were measured by radioimmunoassay in peripheral blood samples from 10 tammar wallabies after their pouch young were removed to terminate embryonic diapause [32].
• PCR derived cDNA clones for X-linked phosphoglycerate kinase-1 in a marsupial, the tammar wallaby (Macropus eugenii) [33].
• Mapping the distribution of the telomeric sequence (T2AG3)n in the Macropodoidea (Marsupialia), by fluorescence in situ hybridization. I. The swamp wallaby, Wallabia bicolor [34].
• When total serum bilirubin level reached 6.0 mg/dl (102.6 micromol/l), eligible infants were randomly assigned to four study groups: conventional, fiberoptic Wallaby, fiberoptic Biliblanket, and combined phototherapy [35].

References