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Disease relevance of Macropodidae


High impact information on Macropodidae

  • Although marsupials have been separated from eutherian mammals for approximately 100 million years, homologues of SRY have been localised to the Y chromosome of two unrelated marsupial species, the tammar wallaby and the Darling Downs dunnart [6].
  • The region harboring the gene for lysine tRNA (tRNA-Lys) in the mtDNA of other vertebrates is in the wallaroo occupied by a sequence (tRNA-Lys) that lacks both an anticodon loop as well as the anticodon for the amino acid lysine [7].
  • The ontogeny of Müllerian inhibiting substance (MIS) production by the developing testis of an Australian marsupial, the tammar wallaby (Macropus eugenii), was determined during pouch life using an organ-culture bioassay of mouse fetal urogenital ridge [8].
  • We report here the isolation of WAP from the milk of a marsupial, the tammar wallaby (Macropus eugenii) [9].
  • We found that the wallaby has a SWS1 class pigment of 346 amino acids [10].

Chemical compound and disease context of Macropodidae


Biological context of Macropodidae


Anatomical context of Macropodidae

  • Fluorescent and radioisotope techniques were used sequentially to determine the activity of pathways of glucose metabolism by individual wallaby blastocysts during diapause and 3, 4, 5, 6, 7, 8, and 10 days after removal of pouch young (RPY) [18].
  • The organisation presumably underlies the less extensive searching within the developing superior colliculus to generate retinotopic maps in the quokka and also in tammar wallaby [Marotte, J. Comp Neurol. 293:524-539, 1990] than in the rat [Simon and O'Leary, J. Neurosci. 12:1212-1232, 1992] [19].
  • Characterization and properties of a progesterone receptor in the uterus of the quokka (Setonix brachyurus) [20].
  • Mammary gland lactose concentrations in tammar wallabies are therefore a useful indicator of biosynthetic activity and as an index of lactogenesis but the role, if any, of progesterone withdrawal in lactogenesis remains unclear [21].
  • Inhibitors of protein kinase C [1-(5-isoquinolinyl-sulfonyl)-2-methylpiperazine] and phospholipase A2 [dexamethasone] did not effect DiC8-induced acrosomal loss in wallaby spermatozoa [22].

Associations of Macropodidae with chemical compounds

  • To investigate the mechanism by which androgens virilize the Wolffian ducts in the tammar wallaby, [(3)H]progesterone was incubated with testes from d 10 and 19 pouch young, and radioactivity was recovered in testosterone and androstanediol at both ages [1].
  • Seasonal changes in the circadian plasma melatonin profile of the tammar, Macropus eugenii [23].
  • Micropreparative two-dimensional polyacrylamide gel electrophoresis has been used to separate milk whey proteins from the Tammar wallaby (Macropus eugenii) [24].
  • The unique feature of the female tammar wallaby is that it does not become a seasonally breeding mammal until after puberty, when it has acquired a corpus luteum [25].
  • The data confirm that a local fetal influence is more important than systemic factors, such as estrogen, in the regulation of uterine mesotocin receptors in the tammar wallaby [17].

Gene context of Macropodidae

  • We have identified MKRN1 orthologs from human, mouse, wallaby, chicken, fruitfly, and nematode, underscoring the age and conservation of this gene [26].
  • Genomic imprinting of IGF2, p57(KIP2) and PEG1/MEST in a marsupial, the tammar wallaby [27].
  • The existence of two PGK1 homologous restriction fragments from the X and a large number from the autosomes was also demonstrated by somatic cell hybridization for two other macropodid species, the wallaroo (M. robustus) and the red kangaroo (M. rufus) [28].
  • cDNA sequence of the lymphotoxin beta chain from a marsupial, Macropus eugenii (Tammar wallaby) [29].
  • Northern analysis of total wallaby liver RNA detected transcripts of 1.8 kb for IGFBP-1 and 1.6 kb for IGFBP-2, the same as those observed in the sheep and rat [30].

Analytical, diagnostic and therapeutic context of Macropodidae


  1. Role of the alternate pathway of dihydrotestosterone formation in virilization of the wolffian ducts of the tammar wallaby, Macropus eugenii. Shaw, G., Fenelon, J., Sichlau, M., Auchus, R.J., Wilson, J.D., Renfree, M.B. Endocrinology (2006) [Pubmed]
  2. Adrenal insufficiency and the effects of steroid replacement therapy in the tammar wallaby (Macropus eugenii). Bakker, H.R., Waring, H. J. Endocrinol. (1976) [Pubmed]
  3. Hematology and erythrocyte biochemistry of spectacled hare-wallaby, Lagorchestes conspicillatus (Macropodidae Marsupialia). Agar, N.S., Spencer, P.B. Int. J. Hematol. (1993) [Pubmed]
  4. Oxalate toxicity in a scaly-tailed possum, a Patagonian cavy and a swamp wallaby. Ellis, T.M., Copland, M.D., Gaynor, W.T. J. Wildl. Dis. (1983) [Pubmed]
  5. Pharmacokinetics of oxytetracycline in clinical cases in the red-necked wallaby (Macropus rufogriseus). Kirkwood, J.K., Gulland, F.M., Needham, J.R., Vogler, M.G. Res. Vet. Sci. (1988) [Pubmed]
  6. Widespread expression of the testis-determining gene SRY in a marsupial. Harry, J.L., Koopman, P., Brennan, F.E., Graves, J.A., Renfree, M.B. Nat. Genet. (1995) [Pubmed]
  7. The complete mitochondrial genome of the wallaroo (Macropus robustus) and the phylogenetic relationship among Monotremata, Marsupialia, and Eutheria. Janke, A., Xu, X., Arnason, U. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  8. Müllerian inhibiting substance production and testicular migration and descent in the pouch young of a marsupial. Hutson, J.M., Shaw, G., O, W.S., Short, R.V., Renfree, M.B. Development (1988) [Pubmed]
  9. The gene for a novel member of the whey acidic protein family encodes three four-disulfide core domains and is asynchronously expressed during lactation. Simpson, K.J., Ranganathan, S., Fisher, J.A., Janssens, P.A., Shaw, D.C., Nicholas, K.R. J. Biol. Chem. (2000) [Pubmed]
  10. The cone visual pigments of an Australian marsupial, the tammar wallaby (Macropus eugenii): sequence, spectral tuning, and evolution. Deeb, S.S., Wakefield, M.J., Tada, T., Marotte, L., Yokoyama, S., Marshall Graves, J.A. Mol. Biol. Evol. (2003) [Pubmed]
  11. Virilization of the male pouch young of the tammar wallaby does not appear to be mediated by plasma testosterone or dihydrotestosterone. Wilson, J.D., George, F.W., Shaw, G., Renfree, M.B. Biol. Reprod. (1999) [Pubmed]
  12. Virilization of the urogenital sinus of the tammar wallaby is not unique to 5alpha-androstane-3alpha,17beta-diol. Leihy, M.W., Shaw, G., Wilson, J.D., Renfree, M.B. Mol. Cell. Endocrinol. (2001) [Pubmed]
  13. MHC class II genes of a marsupial, the red-necked wallaby (Macropus rufogriseus): identification of new gene families. Schneider, S., Vincek, V., Tichy, H., Figueroa, F., Klein, J. Mol. Biol. Evol. (1991) [Pubmed]
  14. Linkage of the beta-like omega-globin gene to alpha-like globin genes in an Australian marsupial supports the chromosome duplication model for separation of globin gene clusters. Wheeler, D., Hope, R.M., Cooper, S.J., Gooley, A.A., Holland, R.A. J. Mol. Evol. (2004) [Pubmed]
  15. A eutherian X-linked gene, PDHA1, is autosomal in marsupials: a model for the evolution of a second, testis-specific variant in eutherian mammals. Fitzgerald, J., Wilcox, S.A., Graves, J.A., Dahl, H.H. Genomics (1993) [Pubmed]
  16. Cortisol in fetal fluids and the fetal adrenal at parturition in the tammar wallaby (Macropus eugenii). Ingram, J.N., Shaw, G., Renfree, M.B. Biol. Reprod. (1999) [Pubmed]
  17. Up-regulation of mesotocin receptors in the tammar wallaby myometrium is pregnancy-specific and independent of estrogen. Siebel, A.L., Gehring, H.M., Nave, C.D., Bathgate, R.A., Borchers, C.E., Parry, L.J. Biol. Reprod. (2002) [Pubmed]
  18. Reactivating tammar wallaby blastocysts oxidize glucose. Spindler, R.E., Renfree, M.B., Shaw, G., Gardner, D.K. Biol. Reprod. (1998) [Pubmed]
  19. Axon order in the visual pathway of the quokka wallaby. Chelvanayagam, D.K., Dunlop, S.A., Beazley, L.D. J. Comp. Neurol. (1998) [Pubmed]
  20. Characterization and properties of a progesterone receptor in the uterus of the quokka (Setonix brachyurus). Owen, F.J., Cake, M.H., Bradshaw, S.D. J. Endocrinol. (1982) [Pubmed]
  21. Mammary gland lactose, plasma progesterone and lactogenesis in the marsupial Macropus eugenii. Findlay, L., Ward, K.L., Renfree, M.B. J. Endocrinol. (1983) [Pubmed]
  22. Role of diacylglycerols and calcium in the marsupial acrosome reaction. Mate, K.E., Rodger, J.C. J. Reprod. Fertil. (1993) [Pubmed]
  23. Seasonal changes in the circadian plasma melatonin profile of the tammar, Macropus eugenii. McConnell, S.J. J. Pineal Res. (1986) [Pubmed]
  24. Identification of wallaby milk whey proteins separated by two-dimensional electrophoresis, using amino acid analysis and sequence tagging. Molloy, M.P., Herbert, B.R., Yan, J.X., Williams, K.L., Gooley, A.A. Electrophoresis (1997) [Pubmed]
  25. Puberty in the female tammar wallaby. Williams, S.C., Fletcher, T.P., Renfree, M.B. Biol. Reprod. (1998) [Pubmed]
  26. The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system. Gray, T.A., Hernandez, L., Carey, A.H., Schaldach, M.A., Smithwick, M.J., Rus, K., Marshall Graves, J.A., Stewart, C.L., Nicholls, R.D. Genomics (2000) [Pubmed]
  27. Genomic imprinting of IGF2, p57(KIP2) and PEG1/MEST in a marsupial, the tammar wallaby. Suzuki, S., Renfree, M.B., Pask, A.J., Shaw, G., Kobayashi, S., Kohda, T., Kaneko-Ishino, T., Ishino, F. Mech. Dev. (2005) [Pubmed]
  28. Phosphoglycerate kinase pseudogenes in the tammar wallaby and other macropodid marsupials. Cooper, D.W., Holland, E.A., Rudman, K., Donald, J.A., Zehavi-Feferman, R., McKenzie, L.M., Sinclair, A.H., Spencer, J.A., Graves, J.A., Poole, W.E. Mamm. Genome (1994) [Pubmed]
  29. cDNA sequence of the lymphotoxin beta chain from a marsupial, Macropus eugenii (Tammar wallaby). Harrison, G.A., Deane, E.M. J. Interferon Cytokine Res. (1999) [Pubmed]
  30. Analysis of insulin-like growth factor binding proteins in the tammar wallaby, Macropus eugenii. Carr, J.M., Owens, J.A., Baudinette, R.V., Wallace, J.C. Gen. Comp. Endocrinol. (1995) [Pubmed]
  31. Graded expression of EphA3 in the retina and ephrin-A2 in the superior colliculus during initial development of coarse topography in the wallaby retinocollicular projection. Stubbs, J., Palmer, A., Vidovic, M., Marotte, L.R. Eur. J. Neurosci. (2000) [Pubmed]
  32. Concentrations of oestradiol-17 beta in plasma and corpora lutea throughout pregnancy in the tammar, Macropus eugenii. Shaw, G., Renfree, M.B. J. Reprod. Fertil. (1984) [Pubmed]
  33. PCR derived cDNA clones for X-linked phosphoglycerate kinase-1 in a marsupial, the tammar wallaby (Macropus eugenii). Zehavi-Feferman, R., Cooper, D.W. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  34. Mapping the distribution of the telomeric sequence (T2AG3)n in the Macropodoidea (Marsupialia), by fluorescence in situ hybridization. I. The swamp wallaby, Wallabia bicolor. Metcalfe, C.J., Eldridge, M.D., Toder, R., Johnston, P.G. Chromosome Res. (1998) [Pubmed]
  35. Which phototherapy system is most effective in lowering serum bilirubin in very preterm infants? Romagnoli, C., Zecca, E., Papacci, P., Vento, G., Girlando, P., Latella, C. Fetal. Diagn. Ther. (2006) [Pubmed]
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