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Gene Review

Rela  -  v-rel reticuloendotheliosis viral oncogene...

Mus musculus

Synonyms: Nfkb3, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, Transcription factor p65, p65, ...
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Disease relevance of Rela


High impact information on Rela


Biological context of Rela

  • We have determined the genomic structure of mouse Rela and promoter, and have mapped the gene to chromosome 19B1-3 [4].

Analytical, diagnostic and therapeutic context of Rela


  1. Pathogenic Escherichia coli increase Cl- secretion from intestinal epithelia by upregulating galanin-1 receptor expression. Hecht, G., Marrero, J.A., Danilkovich, A., Matkowskyj, K.A., Savkovic, S.D., Koutsouris, A., Benya, R.V. J. Clin. Invest. (1999) [Pubmed]
  2. Listeria monocytogenes infection enhances transcription factor NF-kappa B in P388D1 macrophage-like cells. Hauf, N., Goebel, W., Serfling, E., Kuhn, M. Infect. Immun. (1994) [Pubmed]
  3. A high dose of ionizing radiation induces tissue-specific activation of nuclear factor-kappaB in vivo. Zhou, D., Brown, S.A., Yu, T., Chen, G., Barve, S., Kang, B.C., Thompson, J.S. Radiat. Res. (1999) [Pubmed]
  4. Genomic structure and chromosome location of the mouse RelA p65 gene (Rela). Lemmer, E.R., Welch, J.L., Tsai, T., Keck-Waggoner, C.L., Huh, C., Zimonjic, D.B., Popescu, N.C., Thorgeirsson, S.S. Cytogenet. Cell Genet. (2000) [Pubmed]
  5. NF kappa B activation in mouse pituitary: comparison of response to interleukin-1 beta and lipopolysaccharide. Parnet, P., Pousset, F., Laye, S. J. Neuroendocrinol. (2003) [Pubmed]
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