Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Rela - v-rel reticuloendotheliosis viral oncogene...

Mus musculus

Synonyms: Nfkb3, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, Transcription factor p65, p65, ...

Hauf, N. et al., Hecht, G. et al., Lemmer, E.R. et al., Parnet, P. et al., Zhou, D. et al.

Parnet, Pousset, Laye,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Rela

Pathogenic Escherichia coli, but not nonpathogenic E. coli, activate a p50/p65 NF-kappa B complex that binds to oligonucleotides corresponding to a recognition site located within the 5' flanking region of the human GAL1R gene [1].

High impact information on Rela

Infection experiments with different nonhemolytic mutants of L. monocytogenes and the use of the phagocytosis inhibitor cytochalasin B suggest that events prior to invasion and escape of the bacteria from the phagosome into the cytoplasm enhance the nuclear transport of p50/p65 NF-kappa B components [2].
In mesenteric lymph nodes, the heterodimerized Rel/Rela NF-kappaB was also activated [3].
Genomic structure and chromosome location of the mouse RelA p65 gene (Rela) [4].

Biological context of Rela

We have determined the genomic structure of mouse Rela and promoter, and have mapped the gene to chromosome 19B1-3 [4].

Analytical, diagnostic and therapeutic context of Rela

Using immunohistochemistry with an antibody directed against the p65 NF kappa B subunit, a rapid and transient NF kappa B response to LPS was observed [5].

References

Pathogenic Escherichia coli increase Cl- secretion from intestinal epithelia by upregulating galanin-1 receptor expression. Hecht, G., Marrero, J.A., Danilkovich, A., Matkowskyj, K.A., Savkovic, S.D., Koutsouris, A., Benya, R.V. J. Clin. Invest. (1999) [Pubmed]
Listeria monocytogenes infection enhances transcription factor NF-kappa B in P388D1 macrophage-like cells. Hauf, N., Goebel, W., Serfling, E., Kuhn, M. Infect. Immun. (1994) [Pubmed]
A high dose of ionizing radiation induces tissue-specific activation of nuclear factor-kappaB in vivo. Zhou, D., Brown, S.A., Yu, T., Chen, G., Barve, S., Kang, B.C., Thompson, J.S. Radiat. Res. (1999) [Pubmed]
Genomic structure and chromosome location of the mouse RelA p65 gene (Rela). Lemmer, E.R., Welch, J.L., Tsai, T., Keck-Waggoner, C.L., Huh, C., Zimonjic, D.B., Popescu, N.C., Thorgeirsson, S.S. Cytogenet. Cell Genet. (2000) [Pubmed]
NF kappa B activation in mouse pituitary: comparison of response to interleukin-1 beta and lipopolysaccharide. Parnet, P., Pousset, F., Laye, S. J. Neuroendocrinol. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

RELA	Bos taurus
RELA	Canis lupus familiaris
rela	Danio rerio
RELA	Gallus gallus
RELA	Homo sapiens
RELA	Macaca mulatta
RELA	Pan troglodytes
Rela	Rattus norvegicus
rela	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.