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RELA  -  v-rel avian reticuloendotheliosis viral...

Homo sapiens

Synonyms: NFKB3, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, Transcription factor p65, p65
 
 
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Disease relevance of RELA

 

High impact information on RELA

  • We show the transcription factor OCT1 binds TNF(-857T) but not TNF(-857C), and interacts in vitro and in vivo with the pro-inflammatory NF(-kappa)B transcription factor p65 subunit at an adjacent binding site [3].
  • Determination of the kinetics of nuclear entry shows marked differences for the two components; the entry of IkappaBalpha occurs more rapidly than RELA [4].
  • In contrast, induction of c-JUN does not require EGFR activity and p65/RELA induction is only partially dependent on these kinases [5].
  • Direct measurement of mRNAs showed increased gene expression of both types of transcription factors in chondroinduced hDFs, including NFKB2 (290% of control), RELA (160%), and GATA2 (190%) [6].
  • MS association was excluded for the NFKB1 and NFKB3 genes, which show remarkably low degrees of polymorphism [7].
 

Biological context of RELA

 

Anatomical context of RELA

  • Additionally, the percentage of biopsies with nuclear localization of p65/RELA in epithelial cells increased with advancing pathology grade, suggesting that NF-kappaB transcriptional activity was induced more frequently in advanced IEN lesions [9].
 

Associations of RELA with chemical compounds

 

Physical interactions of RELA

 

Regulatory relationships of RELA

 

Other interactions of RELA

 

Analytical, diagnostic and therapeutic context of RELA

References

  1. Pulse transit time by R-wave-gated infrared photoplethysmography: review of the literature and personal experience. Naschitz, J.E., Bezobchuk, S., Mussafia-Priselac, R., Sundick, S., Dreyfuss, D., Khorshidi, I., Karidis, A., Manor, H., Nagar, M., Peck, E.R., Peck, S., Storch, S., Rosner, I., Gaitini, L. Journal of clinical monitoring and computing. (2004) [Pubmed]
  2. Plasma osteopontin levels are elevated in non-ST-segment elevation acute coronary syndromes. Coskun, S., Atalar, E., Ozturk, E., Yavuz, B., Ozer, N., Goker, H., Ov??n??, K., Aks??yek, S., Kes, S., Sivri, B., Kirazli, S., Ozmen, F. Journal of the National Medical Association (2006) [Pubmed]
  3. Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors. van Heel, D.A., Udalova, I.A., De Silva, A.P., McGovern, D.P., Kinouchi, Y., Hull, J., Lench, N.J., Cardon, L.R., Carey, A.H., Jewell, D.P., Kwiatkowski, D. Hum. Mol. Genet. (2002) [Pubmed]
  4. Dynamic shuttling of nuclear factor kappa B between the nucleus and cytoplasm as a consequence of inhibitor dissociation. Carlotti, F., Dower, S.K., Qwarnstrom, E.E. J. Biol. Chem. (2000) [Pubmed]
  5. JNK activation is critical for Aplidin-induced apoptosis. Cuadrado, A., González, L., Suárez, Y., Martínez, T., Muñoz, A. Oncogene (2004) [Pubmed]
  6. Identification of cis and trans-acting transcriptional regulators in chondroinduced fibroblasts from the pre-phenotypic gene expression profile. Yates, K.E. Gene (2006) [Pubmed]
  7. Inhibitors in the NFkappaB cascade comprise prime candidate genes predisposing to multiple sclerosis, especially in selected combinations. Miterski, B., Böhringer, S., Klein, W., Sindern, E., Haupts, M., Schimrigk, S., Epplen, J.T. Genes Immun. (2002) [Pubmed]
  8. The human NFKB3 gene encoding the p65 subunit of transcription factor NF-kappa B is located on chromosome 11q12. Deloukas, P., Dauwerse, J.G., van Ommen, G.J., van Loon, A.P. Genomics (1994) [Pubmed]
  9. Increased staining for phospho-Akt, p65/RELA and cIAP-2 in pre-neoplastic human bronchial biopsies. Tichelaar, J.W., Zhang, Y., leRiche, J.C., Biddinger, P.W., Lam, S., Anderson, M.W. BMC Cancer (2005) [Pubmed]
  10. Sp1 and NFkappaB pathways are regulated in brain in response to acute and chronic ethanol. Rulten, S.L., Ripley, T.L., Hunt, C.L., Stephens, D.N., Mayne, L.V. Genes Brain Behav. (2006) [Pubmed]
  11. Is this really a muscle cramp? Eaton, J.M. Postgraduate medicine. (1989) [Pubmed]
  12. PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit. Tanaka, T., Grusby, M.J., Kaisho, T. Nat. Immunol. (2007) [Pubmed]
  13. Nuclear NF-kappaB p65 phosphorylation at serine 276 by protein kinase A contributes to the malignant phenotype of head and neck cancer. Arun, P., Brown, M.S., Ehsanian, R., Chen, Z., Van Waes, C. Clin. Cancer Res. (2009) [Pubmed]
  14. Femtomol sensitivity post-digest (18)O labeling for relative quantification of differential protein complex composition. Bantscheff, M., Dümpelfeld, B., Kuster, B. Rapid Commun. Mass Spectrom. (2004) [Pubmed]
  15. Human recombinant PLD2 can repress p65 activity of guinea pigs of chronic asthma in vivo. Zhu, L., Zou, W., Yu, C., Lin, J., He, X. Cell. Mol. Immunol. (2006) [Pubmed]
  16. REL proto-oncogene is frequently amplified in extranodal diffuse large cell lymphoma. Houldsworth, J., Mathew, S., Rao, P.H., Dyomina, K., Louie, D.C., Parsa, N., Offit, K., Chaganti, R.S. Blood (1996) [Pubmed]
 
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