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Gene Review

Rem1  -  rad and gem related GTP binding protein 1

Mus musculus

Synonyms: E030011C07Rik, GTP-binding protein REM 1, Rad and Gem-like GTP-binding protein 1, Rem
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Psychiatry related information on Rem1

  • Mice were treated with either vehicle, SCH (0.015 mg/kg), remoxipride (Rem, 0.3 mg/kg), CPP (2.5 mg/kg) or NBQX (10.0 mg/kg), followed 30 min later by vehicle or 75 mg/kg TDF (TDF), twice a week for 7 weeks, with locomotor activity measured post-dosing once a week [1].

High impact information on Rem1

  • Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases [2].
  • Rem is expressed in primary skeletal myoblasts and, when overexpressed in C2C12 myoblasts, wild-type Rem inhibits L type Ca2+ channel activity [2].
  • The administration of lipopolysaccharide to mice, a potent activator of the inflammatory and immune systems, results in the general repression of Rem mRNA levels in a dose- and time-dependent manner [3].
  • Ribonuclease protection analysis found Rem to be expressed at comparatively high levels in cardiac muscle and at moderate levels in lung, skeletal muscle, and kidney [3].
  • The activity of these compounds largely paralleled that of bis(2-chloroethyl)-N-nitrosourea (BCNU), except for those cell lines which exhibited the Rem phenotype; triazenes were more active in those lines than BCNU [4].

Biological context of Rem1

  • These results suggest that 14-3-3 may allow the recruitment of distinct proteins that participate in Rem-mediated signal transduction pathways [5].
  • Examination of the interaction between 14-3-3zeta and various Rem deletion mutants mapped a critical binding site to the C-terminus of Rem [5].
  • Interestingly, nuclear targeting of Rad and Rem can relocalize and sequester the beta-subunit to the nucleus, thus providing a novel mechanism for Ca2+ channel downregulation [6].

Analytical, diagnostic and therapeutic context of Rem1


  1. Development of behavioral sensitization to the cocaine-like fungicide triadimefon is prevented by AMPA, NMDa, DA D1 but not DA D2 receptor antagonists. Reeves, R., Thiruchelvam, M., Cory-Slechta, D.A. Toxicol. Sci. (2004) [Pubmed]
  2. Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases. Finlin, B.S., Crump, S.M., Satin, J., Andres, D.A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Rem is a new member of the Rad- and Gem/Kir Ras-related GTP-binding protein family repressed by lipopolysaccharide stimulation. Finlin, B.S., Andres, D.A. J. Biol. Chem. (1997) [Pubmed]
  4. 1,3-Dialkyl-3-acyltriazenes, a novel class of antineoplastic alkylating agents. Smith, R.H., Scudiero, D.A., Michejda, C.J. J. Med. Chem. (1990) [Pubmed]
  5. Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins. Finlin, B.S., Andres, D.A. Arch. Biochem. Biophys. (1999) [Pubmed]
  6. Nuclear sequestration of beta-subunits by Rad and Rem is controlled by 14-3-3 and calmodulin and reveals a novel mechanism for Ca2+ channel regulation. Béguin, P., Mahalakshmi, R.N., Nagashima, K., Cher, D.H., Ikeda, H., Yamada, Y., Seino, Y., Hunziker, W. J. Mol. Biol. (2006) [Pubmed]
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