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Gene Review:

Rnu6 - U6 small nuclear RNA

Mus musculus

Lund, E. et al., Zeng, Q. et al., Hinkley, C.S. et al., Rincon, J.C. et al., Kunkel, G.R. et al.

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High impact information on Rnu6

Spliceosomal U6 small nuclear RNA (U6 RNA) in species as diverse as man, frog, fruitfly, and soybean have at their 3' ends a cyclic 2',3'-phosphate (greater than p) apparently derived from uridylic acid residues that were added post-transcriptionally [1].
A DNA fragment homologous to U6 small nuclear RNA was isolated from a human genomic library and sequenced [2].
This putative promoter structure contrasts with that of the ciliate telomerase-RNA genes whose structure resembles RNA polymerase III U6 small nuclear RNA (snRNA) promoters [3].

Analytical, diagnostic and therapeutic context of Rnu6

Molecular cloning of a cDNA encoding human SPH-binding factor, a conserved protein that binds to the enhancer-like region of the U6 small nuclear RNA gene promoter [4].
Reduction of EGFR tumor expression levels using an antisense EGFR sequence under the control of the U6 small nuclear RNA promoter abrogates tumor growth in a head and neck xenograft model [5].

References

Cyclic 2',3'-phosphates and nontemplated nucleotides at the 3' end of spliceosomal U6 small nuclear RNA's. Lund, E., Dahlberg, J.E. Science (1992) [Pubmed]
U6 small nuclear RNA is transcribed by RNA polymerase III. Kunkel, G.R., Maser, R.L., Calvet, J.P., Pederson, T. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
The mouse telomerase RNA 5"-end lies just upstream of the telomerase template sequence. Hinkley, C.S., Blasco, M.A., Funk, W.D., Feng, J., Villeponteau, B., Greider, C.W., Herr, W. Nucleic Acids Res. (1998) [Pubmed]
Molecular cloning of a cDNA encoding human SPH-binding factor, a conserved protein that binds to the enhancer-like region of the U6 small nuclear RNA gene promoter. Rincon, J.C., Engler, S.K., Hargrove, B.W., Kunkel, G.R. Nucleic Acids Res. (1998) [Pubmed]
Lack of toxicity of EGFR antisense gene therapy. Zeng, Q., Kanter, P.M., Dhir, R., Gooding, W.E., Huang, L., Grandis, J.R. J. Exp. Ther. Oncol. (2002) [Pubmed]

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