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Gene Review

Tep1  -  telomerase associated protein 1

Mus musculus

Synonyms: Telomerase protein 1, Telomerase protein component 1, Telomerase-associated protein 1, Tp1, p240, ...
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Disease relevance of Tep1


High impact information on Tep1


Chemical compound and disease context of Tep1


Biological context of Tep1


Anatomical context of Tep1


Associations of Tep1 with chemical compounds


Physical interactions of Tep1

  • TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA repeat binding factor 1 (TRF1) and affects telomere length by a telomerase-dependent mechanism [22].

Regulatory relationships of Tep1


Other interactions of Tep1


Analytical, diagnostic and therapeutic context of Tep1


  1. Short telomeres, even in the presence of telomerase, limit tissue renewal capacity. Hao, L.Y., Armanios, M., Strong, M.A., Karim, B., Feldser, D.M., Huso, D., Greider, C.W. Cell (2005) [Pubmed]
  2. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Chang, S., Multani, A.S., Cabrera, N.G., Naylor, M.L., Laud, P., Lombard, D., Pathak, S., Guarente, L., DePinho, R.A. Nat. Genet. (2004) [Pubmed]
  3. Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery. Rudolph, K.L., Chang, S., Millard, M., Schreiber-Agus, N., DePinho, R.A. Science (2000) [Pubmed]
  4. Genes and pathways downstream of telomerase in melanoma metastasis. Bagheri, S., Nosrati, M., Li, S., Fong, S., Torabian, S., Rangel, J., Moore, D.H., Federman, S., Laposa, R.R., Baehner, F.L., Sagebiel, R.W., Cleaver, J.E., Haqq, C., Debs, R.J., Blackburn, E.H., Kashani-Sabet, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  5. Telomere dysfunction increases mutation rate and genomic instability. Hackett, J.A., Feldser, D.M., Greider, C.W. Cell (2001) [Pubmed]
  6. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Hemann, M.T., Strong, M.A., Hao, L.Y., Greider, C.W. Cell (2001) [Pubmed]
  7. Telomerase activity is not altered by regular strenuous exercise in skeletal muscle or by sarcoma in liver of rats. Radak, Z., Taylor, A.W., Sasvari, M., Ohno, H., Horkay, B., Furesz, J., Gaal, D., Kanel, T. Redox Rep. (2001) [Pubmed]
  8. Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity. Kang, H.J., Choi, Y.S., Hong, S.B., Kim, K.W., Woo, R.S., Won, S.J., Kim, E.J., Jeon, H.K., Jo, S.Y., Kim, T.K., Bachoo, R., Reynolds, I.J., Gwag, B.J., Lee, H.W. J. Neurosci. (2004) [Pubmed]
  9. TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Nakayama, J., Saito, M., Nakamura, H., Matsuura, A., Ishikawa, F. Cell (1997) [Pubmed]
  10. Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo. Liu, Y., Snow, B.E., Hande, M.P., Baerlocher, G., Kickhoefer, V.A., Yeung, D., Wakeham, A., Itie, A., Siderovski, D.P., Lansdorp, P.M., Robinson, M.O., Harrington, L. Mol. Cell. Biol. (2000) [Pubmed]
  11. Genetic analysis of myc and telomerase interactions in vivo. Flores, I., Evan, G., Blasco, M.A. Mol. Cell. Biol. (2006) [Pubmed]
  12. Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase. LaBranche, H., Dupuis, S., Ben-David, Y., Bani, M.R., Wellinger, R.J., Chabot, B. Nat. Genet. (1998) [Pubmed]
  13. Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis. Blasco, M.A., Rizen, M., Greider, C.W., Hanahan, D. Nat. Genet. (1996) [Pubmed]
  14. Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability. d'Adda di Fagagna, F., Hande, M.P., Tong, W.M., Lansdorp, P.M., Wang, Z.Q., Jackson, S.P. Nat. Genet. (1999) [Pubmed]
  15. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Blasco, M.A., Lee, H.W., Hande, M.P., Samper, E., Lansdorp, P.M., DePinho, R.A., Greider, C.W. Cell (1997) [Pubmed]
  16. Telomerase regulation and stem cell behaviour. Flores, I., Benetti, R., Blasco, M.A. Curr. Opin. Cell Biol. (2006) [Pubmed]
  17. Regulation of telomere length and telomerase in T and B cells: a mechanism for maintaining replicative potential. Weng, N.P., Hathcock, K.S., Hodes, R.J. Immunity (1998) [Pubmed]
  18. Telomerase activation and rejuvenation of telomere length in stimulated T cells derived from serially transplanted hematopoietic stem cells. Allsopp, R.C., Cheshier, S., Weissman, I.L. J. Exp. Med. (2002) [Pubmed]
  19. Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. Senkal, C.E., Ponnusamy, S., Rossi, M.J., Sundararaj, K., Szulc, Z., Bielawski, J., Bielawska, A., Meyer, M., Cobanoglu, B., Koybasi, S., Sinha, D., Day, T.A., Obeid, L.M., Hannun, Y.A., Ogretmen, B. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  20. Telomere dysfunction results in enhanced organismal sensitivity to the alkylating agent N-methyl-N-nitrosourea. González-Suárez, E., Goytisolo, F.A., Flores, J.M., Blasco, M.A. Cancer Res. (2003) [Pubmed]
  21. Glutathione regulates telomerase activity in 3T3 fibroblasts. Borrás, C., Esteve, J.M., Viña, J.R., Sastre, J., Viña, J., Pallardó, F.V. J. Biol. Chem. (2004) [Pubmed]
  22. Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway. Chiang, Y.J., Kim, S.H., Tessarollo, L., Campisi, J., Hodes, R.J. Mol. Cell. Biol. (2004) [Pubmed]
  23. Stem cell factor activates telomerase in mouse mitotic spermatogonia and in primordial germ cells. Dolci, S., Levati, L., Pellegrini, M., Faraoni, I., Graziani, G., Di Carlo, A., Geremia, R. J. Cell. Sci. (2002) [Pubmed]
  24. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Keegan, C.E., Hutz, J.E., Else, T., Adamska, M., Shah, S.P., Kent, A.E., Howes, J.M., Beamer, W.G., Hammer, G.D. Hum. Mol. Genet. (2005) [Pubmed]
  25. Identification of functional domains and dominant negative mutations in vertebrate telomerase RNA using an in vivo reconstitution system. Martin-Rivera, L., Blasco, M.A. J. Biol. Chem. (2001) [Pubmed]
  26. Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage. Armstrong, L., Saretzki, G., Peters, H., Wappler, I., Evans, J., Hole, N., von Zglinicki, T., Lako, M. Stem Cells (2005) [Pubmed]
  27. Expression of mouse telomerase catalytic subunit in embryos and adult tissues. Martín-Rivera, L., Herrera, E., Albar, J.P., Blasco, M.A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  28. Mice deficient in telomerase activity develop hypertension because of an excess of endothelin production. Pérez-Rivero, G., Ruiz-Torres, M.P., Rivas-Elena, J.V., Jerkic, M., Díez-Marques, M.L., Lopez-Novoa, J.M., Blasco, M.A., Rodríguez-Puyol, D. Circulation (2006) [Pubmed]
  29. Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs. Espejel, S., Klatt, P., Ménissier-de Murcia, J., Martín-Caballero, J., Flores, J.M., Taccioli, G., de Murcia, G., Blasco, M.A. J. Cell Biol. (2004) [Pubmed]
  30. Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. González-Suárez, E., Samper, E., Ramírez, A., Flores, J.M., Martín-Caballero, J., Jorcano, J.L., Blasco, M.A. EMBO J. (2001) [Pubmed]
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