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Gene Review:

Rpl6 - ribosomal protein L6

Mus musculus

Synonyms: 60S ribosomal protein L6, TAX-responsive enhancer element-binding protein 107, TAXREB107, Taxreb107

Wittlin, S. et al., Wang, J. et al.

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Disease relevance of Rpl6

Expression of HTLV-I viral protein Tax mildly but reproducibly induced RpL6/Taxreb107 mRNA and promoter activity [1].

High impact information on Rpl6

Identification of Taxreb107 as a lactogenic hormone responsive gene in mammary epithelial cells [2].
Increased Taxreb107 expression was confirmed following prolactin and dexamethasone-induced differentiation of SCp2 and HC11 mammary epithelial cells [2].
Taxreb107 RNA levels were developmentally regulated in the mouse mammary gland, where levels increased substantially during mid- and late pregnancy and persisted during lactation [2].
One of the cDNAs identified encoded the DNA-binding protein Taxreb107, originally identified as a HTLV-I Tax responsive element binding protein [2].
Ribosomal protein (Rp) L6 is also defined as Taxreb107 (Tax responsive element binding protein 107) for its binding activity to the long terminal repeats of human T cell leukemia virus (HTLV)-I [1].

Biological context of Rpl6

Overexpression of an antisense Taxreb107 cDNA construct or antisense oligonucleotide in HC11 mammary epithelial cells attenuated milk protein gene expression following prolactin and dexamethasone treatment [2].

Anatomical context of Rpl6

These findings indicate a role for Taxreb107 as a lactogenic hormone-responsive gene during differentiation of the mammary gland [2].

References

Cloning of mouse genomic ribosomal protein L6 gene and analysis of its promoter. Wang, J., Yang, X., Zhou, P., Han, H. Biochim. Biophys. Acta (2002) [Pubmed]
Identification of Taxreb107 as a lactogenic hormone responsive gene in mammary epithelial cells. Wittlin, S., Sutherland, K.D., Visvader, J.E., Lindeman, G.J. Biochim. Biophys. Acta (2003) [Pubmed]

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