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Gene Review

RPL6  -  ribosomal protein L6

Homo sapiens

Synonyms: 60S ribosomal protein L6, L6, Neoplasm-related protein C140, SHUJUN-2, TAXREB107, ...
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Disease relevance of RPL6


High impact information on RPL6


Biological context of RPL6


Anatomical context of RPL6

  • Immunoblot analysis showed that polyclonal antibody against TAXREB107 specifically recognized a 34-kD protein in Jurkat cells [8].

Associations of RPL6 with chemical compounds


Other interactions of RPL6


Analytical, diagnostic and therapeutic context of RPL6

  • We have refined the position of RPL6, using two different radiation hybrid panels [1].
  • Northern and Western blot analysis confirmed that RPL6 was overexpressed in SGC7901/ADR cells [2].
  • Southern blot analysis on a hybrid mapping panel confirmed the presence of at least one autosomal gene for TXREB, and Northern blot hybridization with the 599-bp putative intron probe confirmed that the sequence is not part of the mature mRNA [7].
  • Ribosomal protein L6, ribosomal protein S7, chaperonin 10, and cytochrome oxidase I were identified to be up-regulated 4- to 5-fold after 70% partial hepatectomy [9].


  1. The human ribosomal protein L6 gene in a critical region for Noonan syndrome. Kenmochi, N., Yoshihama, M., Higa, S., Tanaka, T. J. Hum. Genet. (2000) [Pubmed]
  2. Regulation of multidrug resistance by ribosomal protein l6 in gastric cancer cells. Du, J., Shi, Y., Pan, Y., Jin, X., Liu, C., Liu, N., Han, Q., Lu, Y., Qiao, T., Fan, D. Cancer Biol. Ther. (2005) [Pubmed]
  3. Intracellular association of FGF-2 with the ribosomal protein L6/TAXREB107. Shen, B., Arese, M., Gualandris, A., Rifkin, D.B. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  4. Paroxysmal nocturnal hemoglobinuria: Differential gene expression of EGR-1 and TAXREB107. Lyakisheva, A., Felda, O., Ganser, A., Schmidt, R.E., Schubert, J. Exp. Hematol. (2002) [Pubmed]
  5. Identification of TAXREB107 as an erythropoietin early response gene. Li, R., Madden, H., Sytkowski, A.J. AIDS Res. Hum. Retroviruses (1999) [Pubmed]
  6. Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6. Zaman, G.J. Nucleic Acids Res. (1993) [Pubmed]
  7. Identification of a TXREB pseudogene (TXREBP) located between the genes for p55 (MPP1) and G6PD on Xq28. Das, S., Gitschier, J. Genomics (1994) [Pubmed]
  8. Isolation of a cDNA clone encoding DNA-binding protein (TAXREB107) that binds specifically to domain C of the tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. Morita, T., Sato, T., Nyunoya, H., Tsujimoto, A., Takahara, J., Irino, S., Shimotohno, K. AIDS Res. Hum. Retroviruses (1993) [Pubmed]
  9. Identification and characterization of differentially expressed genes in the early response phase during liver regeneration. Xu, W., Wang, S., Wang, G., Wei, H., He, F., Yang, X. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
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