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Gene Review

PDE12  -  phosphodiesterase 12

Homo sapiens

Synonyms: 2',5'-phosphodiesterase 12, 2'-PDE, 2-PDE, DKFZp667B1218, Mitochondrial deadenylase
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High impact information on 2'-PDE

  • We found a putative 2'-PDE band on SDS-PAGE by successive six-step chromatographies from ammonium sulfate precipitates of bovine liver and identified a partial amino acid sequence of the human 2'-PDE by mass spectrometry [1].
  • Based on the full-length sequence of the human 2'-PDE obtained by in silico expressed sequence tag assembly, the gene was cloned by reverse transcription-PCR [1].
  • Although 2',5'-OASs and RNase L have been molecularly cloned and studied well, the identification of 2'-PDE has remained elusive [1].
  • The 2-5A system is modulated by 5'-triphosphorylated, 2',5'-phosphodiester-linked oligoadenylates (2-5A), which are synthesized by 2',5'-oligoadenylate synthetases (2',5'-OASs), inactivated by 5'-phosphatase and completely degraded by 2'-phosphodiesterase (2'-PDE) [1].
  • Competition of 125I-beta-glucosidase uptake by various carbohydrate-containing fractions indicates that the best inhibitors are those with 2 PDE, either with or without sulfate esters [2].

Biological context of 2'-PDE


Anatomical context of 2'-PDE


Associations of 2'-PDE with chemical compounds

  • 1. The reactivities of aromatic and aliphatic thiols with 2-pyridyldithioethanol (2-PDE), a small molecule disulfide, were determined [5].

Other interactions of 2'-PDE

  • 2'-Phosphodiesterase activity was investigated, by measuring either the disappearance of (2',5')oligo(adenylate) or the release of 5'AMP, in several human cell lines (RSa, IFr, HEC-1, WGAr and HeLa) possessing different sensitivities to interferon, and treated or untreated with human interferon [4].
  • Mouse L cells appeared to contain two different 2-5A synthetase activities, one of which could be separated from 2'-phosphodiesterase activity, which was only cytosolic [6].


  1. Identification of 2'-phosphodiesterase, which plays a role in the 2-5A system regulated by interferon. Kubota, K., Nakahara, K., Ohtsuka, T., Yoshida, S., Kawaguchi, J., Fujita, Y., Ozeki, Y., Hara, A., Yoshimura, C., Furukawa, H., Haruyama, H., Ichikawa, K., Yamashita, M., Matsuoka, T., Iijima, Y. J. Biol. Chem. (2004) [Pubmed]
  2. Interaction of Dictyostelium discoideum lysosomal enzymes with the mammalian phosphomannosyl receptor. The importance of oligosaccharides which contain phosphodiesters. Freeze, H.H. J. Biol. Chem. (1985) [Pubmed]
  3. Genetic organisation of the M protein region in human isolates of group C and G streptococci: two types of multigene regulator-like (mgrC) regions. Geyer, A., Schmidt, K.H. Mol. Gen. Genet. (2000) [Pubmed]
  4. 2'-Phosphodiesterase activity in human cell lines treated or untreated with human interferon. Verhaegen-Lewalle, M., Content, J. Eur. J. Biochem. (1982) [Pubmed]
  5. Effects of aromatic thiols on thiol-disulfide interchange reactions that occur during protein folding. DeCollo, T.V., Lees, W.J. J. Org. Chem. (2001) [Pubmed]
  6. Intracellular metabolism of the interferon mediator, 2-5A, using permeabilized cells. Luxembourg, A. Biochim. Biophys. Acta (1988) [Pubmed]
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