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Gene Review:

Sema3f - sema domain, immunoglobulin domain (Ig),...

Mus musculus

Synonyms: Sema IV, Sema4, Semak, Semaphorin IV, Semaphorin-3F

Chédotal, A. et al., Gammill, L.S. et al.

Chédotal, Del Rio, Ruiz, He, Borrell, de Castro, Ezan, Goodman, Tessier-Lavigne, Sotelo, Soriano,

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High impact information on Sema3f

These data show that Npn2/Sema3f signaling guides neural crest migration through the somite [1].
Furthermore, Npn2 is cell autonomously required for neural crest cells to avoid Sema3f in vitro [1].
An antibody against Neuropilin-1 blocks the repulsive action of Sema III and the entorhinal cortex, but has no effect on Sema IV-induced repulsion [2].
Sema III and Sema IV strongly repel CA1, CA3 and dentate gyrus axons; entorhinal axons are only repelled by Sema III [2].

Anatomical context of Sema3f

The secreted semaphorins Sema III and Sema IV and their receptors Neuropilin-1 and -2 are expressed in the hippocampal formation during appropriate stages [2].

References

Guidance of trunk neural crest migration requires neuropilin 2/semaphorin 3F signaling. Gammill, L.S., Gonzalez, C., Gu, C., Bronner-Fraser, M. Development (2006) [Pubmed]
Semaphorins III and IV repel hippocampal axons via two distinct receptors. Chédotal, A., Del Rio, J.A., Ruiz, M., He, Z., Borrell, V., de Castro, F., Ezan, F., Goodman, C.S., Tessier-Lavigne, M., Sotelo, C., Soriano, E. Development (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

SEMA3F	Bos taurus
SEMA3F	Canis lupus familiaris
sema3fa	Danio rerio
sema3fb	Danio rerio
SEMA3F	Gallus gallus
SEMA3F	Homo sapiens
SEMA3F	Macaca mulatta
SEMA3F	Pan troglodytes
Sema3f	Rattus norvegicus
sema3f	Xenopus (Silurana) tropicalis

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