The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Entorhinal Cortex

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Entorhinal Cortex


Psychiatry related information on Entorhinal Cortex


High impact information on Entorhinal Cortex

  • Homozygous mutant mice are viable at birth, indicating that tailless is not required for prenatal survival; however, adult mutant mice show a reduction in the size of rhinencephalic and limbic structures, including the olfactory, infrarhinal and entorhinal cortex, amygdala and dentate gyrus [11].
  • Here we report direct evidence for the existence of 5-HT3 receptors in rat brain tissue and their distribution, based on high affinity binding of the potent 5-HT3 receptor antagonist 3H-GR65630 to homogenates of rat entorhinal cortex [12].
  • Reverberation of neural activity was detected in the entorhinal cortex and was more prominent when the inhibition due to gamma-aminobutyric acid was slightly suppressed [13].
  • In rats that had received lesions of the entorhinal cortex, axon sprouting of commissural and associational fibers into the denervated molecular layer of the dentate gyrus was paralleled by a spread in the distribution of tritiated kainic acid-binding sites [14].
  • CaMKII Activation in the Entorhinal Cortex Disrupts Previously Encoded Spatial Memory [15].

Chemical compound and disease context of Entorhinal Cortex


Biological context of Entorhinal Cortex


Anatomical context of Entorhinal Cortex


Associations of Entorhinal Cortex with chemical compounds


Gene context of Entorhinal Cortex


Analytical, diagnostic and therapeutic context of Entorhinal Cortex


  1. Expression of c-fos mRNA following seizures evoked from an epileptogenic site in the deep prepiriform cortex: regional distribution in brain as shown by in situ hybridization. Maggio, R., Lanaud, P., Grayson, D.R., Gale, K. Exp. Neurol. (1993) [Pubmed]
  2. Functional activation of somatostatin- and neuropeptide Y-containing neurons in the entorhinal cortex of chronically epileptic rats. Vezzani, A., Monhemius, R., Tutka, P., Milani, R., Samanin, R. Neuroscience (1996) [Pubmed]
  3. Induction of c-fos mRNA and protein in neurons and glia after traumatic brain injury: pharmacological characterization. Dragunow, M., Goulding, M., Faull, R.L., Ralph, R., Mee, E., Frith, R. Exp. Neurol. (1990) [Pubmed]
  4. Excitotoxic lesions of the rat entorhinal cortex. Effects of selective neuronal damage on acquisition and retention of a non-spatial reference memory task. Levisohn, L.F., Isacson, O. Brain Res. (1991) [Pubmed]
  5. Transient upregulation of NCAM mRNA in astrocytes in response to entorhinal cortex lesions and ischemia. Jucker, M., Mondadori, C., Mohajeri, H., Bartsch, U., Schachner, M. Brain Res. Mol. Brain Res. (1995) [Pubmed]
  6. Extended temporal gradient for the retrograde and anterograde amnesia produced by ibotenate entorhinal cortex lesions in mice. Cho, Y.H., Beracochea, D., Jaffard, R. J. Neurosci. (1993) [Pubmed]
  7. Stereologic evidence for persistence of viable neurons in layer II of the entorhinal cortex and the CA1 field in Alzheimer disease. Hof, P.R., Bussière, T., Gold, G., Kövari, E., Giannakopoulos, P., Bouras, C., Perl, D.P., Morrison, J.H. J. Neuropathol. Exp. Neurol. (2003) [Pubmed]
  8. Neurotensin receptor binding abnormalities in the entorhinal cortex in schizophrenia and affective disorders. Hamid, E.H., Hyde, T.M., Egan, M.F., Wolf, S.S., Herman, M.M., Nemeroff, C.B., Kleinman, J.E. Biol. Psychiatry (2002) [Pubmed]
  9. Cognitive impact of neuronal pathology in the entorhinal cortex and CA1 field in Alzheimer's disease. von Gunten, A., Kövari, E., Bussière, T., Rivara, C.B., Gold, G., Bouras, C., Hof, P.R., Giannakopoulos, P. Neurobiol. Aging (2006) [Pubmed]
  10. Rat hippocampal lactate efflux during electroconvulsive shock or stress is differently dependent on entorhinal cortex and adrenal integrity. Krugers, H.J., Jaarsma, D., Korf, J. J. Neurochem. (1992) [Pubmed]
  11. Defective limbic system in mice lacking the tailless gene. Monaghan, A.P., Bock, D., Gass, P., Schwäger, A., Wolfer, D.P., Lipp, H.P., Schütz, G. Nature (1997) [Pubmed]
  12. Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding. Kilpatrick, G.J., Jones, B.J., Tyers, M.B. Nature (1987) [Pubmed]
  13. Entorhinal-hippocampal interactions revealed by real-time imaging. Iijima, T., Witter, M.P., Ichikawa, M., Tominaga, T., Kajiwara, R., Matsumoto, G. Science (1996) [Pubmed]
  14. Plasticity of hippocampal circuitry in Alzheimer's disease. Geddes, J.W., Monaghan, D.T., Cotman, C.W., Lott, I.T., Kim, R.C., Chui, H.C. Science (1985) [Pubmed]
  15. CaMKII Activation in the Entorhinal Cortex Disrupts Previously Encoded Spatial Memory. Yasuda, M., Mayford, M.R. Neuron (2006) [Pubmed]
  16. Adenosine acting via A1 receptors, controls the transition to status epilepticus-like behaviour in an in vitro model of epilepsy. Avsar, E., Empson, R.M. Neuropharmacology (2004) [Pubmed]
  17. Loss of stimulatory effect of guanosine triphosphate on [(35)S]GTPgammaS binding correlates with Alzheimer's disease neurofibrillary pathology in entorhinal cortex and CA1 hippocampal subfield. García-Jiménez, A., Cowburn, R.F., Ohm, T.G., Lasn, H., Winblad, B., Bogdanovic, N., Fastbom, J. J. Neurosci. Res. (2002) [Pubmed]
  18. GluR2/3, NMDAepsilon1 and GABAA receptors in Creutzfeldt-Jakob disease. Ferrer, I., Puig, B. Acta Neuropathol. (2003) [Pubmed]
  19. Increased levels of statin, a marker of cell cycle arrest, in response to hippocampal neuronal injury. Poirier, J., Beffert, U., Dea, D., Alonso, R., O'Donnell, D., Boksa, P. Brain Res. Mol. Brain Res. (1995) [Pubmed]
  20. Quinolinic acid lesion of the rat entorhinal cortex pars medialis produces selective amnesia in allocentric working memory (WM), but not in egocentric WM. Hölscher, C., Schmidt, W.J. Behav. Brain Res. (1994) [Pubmed]
  21. Neuropeptide Y receptor binding sites in rat brain: differential autoradiographic localizations with 125I-peptide YY and 125I-neuropeptide Y imply receptor heterogeneity. Lynch, D.R., Walker, M.W., Miller, R.J., Snyder, S.H. J. Neurosci. (1989) [Pubmed]
  22. Serotonin reduces synaptic excitation in the superficial medial entorhinal cortex of the rat via a presynaptic mechanism. Schmitz, D., Gloveli, T., Empson, R.M., Draguhn, A., Heinemann, U. J. Physiol. (Lond.) (1998) [Pubmed]
  23. BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signaling events. Gooney, M., Messaoudi, E., Maher, F.O., Bramham, C.R., Lynch, M.A. Neurobiol. Aging (2004) [Pubmed]
  24. Excitatory actions of NMDA receptor antagonists in rat entorhinal cortex and cultured entorhinal cortical neurons. Väisänen, J., Lindén, A.M., Lakso, M., Wong, G., Heinemann, U., Castrén, E. Neuropsychopharmacology (1999) [Pubmed]
  25. Basal expression, subcellular distribution, and up-regulation of the proto-oncogene c-JUN in the rat dentate gyrus after unilateral entorhinal cortex lesion. Haas, C.A., Deller, T., Frotscher, M. Neuroscience (1997) [Pubmed]
  26. Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys. Gazzaley, A.H., Siegel, S.J., Kordower, J.H., Mufson, E.J., Morrison, J.H. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  27. Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease. Mufson, E.J., Kordower, J.H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  28. The process of reinnervation in the dentate gyrus of adult rats: time course of increases in mRNA for glial fibrillary acidic protein. Steward, O., Torre, E.R., Phillips, L.L., Trimmer, P.A. J. Neurosci. (1990) [Pubmed]
  29. Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path. Buxbaum, J.D., Thinakaran, G., Koliatsos, V., O'Callahan, J., Slunt, H.H., Price, D.L., Sisodia, S.S. J. Neurosci. (1998) [Pubmed]
  30. Conditioned fear-induced changes in behavior and in the expression of the immediate early gene c-fos: with and without diazepam pretreatment. Beck, C.H., Fibiger, H.C. J. Neurosci. (1995) [Pubmed]
  31. Increased synaptic sprouting in response to estrogen via an apolipoprotein E-dependent mechanism: implications for Alzheimer's disease. Stone, D.J., Rozovsky, I., Morgan, T.E., Anderson, C.P., Finch, C.E. J. Neurosci. (1998) [Pubmed]
  32. Tyrosine hydroxylase-immunoreactive neurons in the temporal lobe in complex partial seizures. Zhu, Z.Q., Armstrong, D.L., Grossman, R.G., Hamilton, W.J. Ann. Neurol. (1990) [Pubmed]
  33. Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain. Frautschy, S.A., Horn, D.L., Sigel, J.J., Harris-White, M.E., Mendoza, J.J., Yang, F., Saido, T.C., Cole, G.M. J. Neurosci. (1998) [Pubmed]
  34. Late onset dementia with argyrophilic grains and subcortical tangles or atypical progressive supranuclear palsy? Masliah, E., Hansen, L.A., Quijada, S., DeTeresa, R., Alford, M., Kauss, J., Terry, R. Ann. Neurol. (1991) [Pubmed]
  35. Synchronous GABA-mediated potentials and epileptiform discharges in the rat limbic system in vitro. Avoli, M., Barbarosie, M., Lücke, A., Nagao, T., Lopantsev, V., Köhling, R. J. Neurosci. (1996) [Pubmed]
  36. Abnormal expression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia. Arnold, S.E., Lee, V.M., Gur, R.E., Trojanowski, J.Q. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  37. Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. Irizarry, M.C., Soriano, F., McNamara, M., Page, K.J., Schenk, D., Games, D., Hyman, B.T. J. Neurosci. (1997) [Pubmed]
  38. Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues. Lee, M.K., Slunt, H.H., Martin, L.J., Thinakaran, G., Kim, G., Gandy, S.E., Seeger, M., Koo, E., Price, D.L., Sisodia, S.S. J. Neurosci. (1996) [Pubmed]
  39. Semaphorins III and IV repel hippocampal axons via two distinct receptors. Chédotal, A., Del Rio, J.A., Ruiz, M., He, Z., Borrell, V., de Castro, F., Ezan, F., Goodman, C.S., Tessier-Lavigne, M., Sotelo, C., Soriano, E. Development (1998) [Pubmed]
  40. Fleecy amyloid deposits in the internal layers of the human entorhinal cortex are comprised of N-terminal truncated fragments of Abeta. Thal, D.R., Sassin, I., Schultz, C., Haass, C., Braak, E., Braak, H. J. Neuropathol. Exp. Neurol. (1999) [Pubmed]
  41. Medial septal area lesions disrupt theta rhythm and cholinergic staining in medial entorhinal cortex and produce impaired radial arm maze behavior in rats. Mitchell, S.J., Rawlins, J.N., Steward, O., Olton, D.S. J. Neurosci. (1982) [Pubmed]
  42. Dentate granule cells are essential for kainic acid-induced wet dog shakes but not for seizures. Grimes, L., McGinty, J., McLain, P., Mitchell, C., Tilson, H., Hong, J. J. Neurosci. (1988) [Pubmed]
  43. Castration enhances expression of glial fibrillary acidic protein and sulfated glycoprotein-2 in the intact and lesion-altered hippocampus of the adult male rat. Day, J.R., Laping, N.J., McNeill, T.H., Schreiber, S.S., Pasinetti, G., Finch, C.E. Mol. Endocrinol. (1990) [Pubmed]
  44. Sema3C and netrin-1 differentially affect axon growth in the hippocampal formation. Steup, A., Lohrum, M., Hamscho, N., Savaskan, N.E., Ninnemann, O., Nitsch, R., Fujisawa, H., Püschel, A.W., Skutella, T. Mol. Cell. Neurosci. (2000) [Pubmed]
WikiGenes - Universities