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Gene Review

SEMA3F  -  sema domain, immunoglobulin domain (Ig),...

Homo sapiens

Synonyms: SEMA-IV, SEMA4, SEMAK, Sema III/F, Sema IV, ...
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Disease relevance of SEMA3F


High impact information on SEMA3F


Chemical compound and disease context of SEMA3F

  • Thus, in this in vivo lung cancer model, SEMA3F has potent antitumor effects, which may impinge on activated integrin and MAPK signaling [1].

Biological context of SEMA3F

  • In the present report, we investigated the attractive/repulsive effects of SEMA3F on cell migration when cells were grown in a three-dimensional system and exposed to a SEMA3F gradient [2].
  • SEMA3F, isolated from a 3p21.3 deletion, has antitumor activity in transfected cells, and protein expression correlates with tumor stage and histology [8].
  • By contrast, only 30-40% reduction in colony formation was seen after the transfection of SEMA3F or SEMA3B variants carrying lung cancer-associated single amino acid missense mutations [6].
  • Two cDNAs corresponding to genes encoded on this P1 clone, semaphorin 3F (SEMA3F) and N23, were tested for their effects on in vitro and in vivo growth characteristics after transfection into mouse A9 cells [9].
  • Moreover, SEMA3F also functioned to block apoptosis of transfected A9 cells treated with Taxol or Adriamycin [9].

Anatomical context of SEMA3F

  • Using retroviral infections, we established stable SEMA3F transfectants in two NSCLC cell lines, NCI-H157 and NCI-H460 [1].
  • SEMA3F inhibited cell attachment and spreading as evidenced by loss of lamellipodia extensions, membrane ruffling, and cell-cell contacts, with cells eventually rounding-up and detaching [8].
  • In normal lung, SEMA3F was found in all epithelial cells at the cytoplasmic membrane and, to a lesser extent, in the cytoplasm [10].

Associations of SEMA3F with chemical compounds


Physical interactions of SEMA3F


Other interactions of SEMA3F


Analytical, diagnostic and therapeutic context of SEMA3F


  1. Selective suppression of in vivo tumorigenicity by semaphorin SEMA3F in lung cancer cells. Kusy, S., Nasarre, P., Chan, D., Potiron, V., Meyronet, D., Gemmill, R.M., Constantin, B., Drabkin, H.A., Roche, J. Neoplasia (2005) [Pubmed]
  2. Semaphorin SEMA3F has a repulsing activity on breast cancer cells and inhibits E-cadherin-mediated cell adhesion. Nasarre, P., Kusy, S., Constantin, B., Castellani, V., Drabkin, H.A., Bagnard, D., Roche, J. Neoplasia (2005) [Pubmed]
  3. Neuropilins in neoplasms: expression, regulation, and function. Bielenberg, D.R., Pettaway, C.A., Takashima, S., Klagsbrun, M. Exp. Cell Res. (2006) [Pubmed]
  4. Expression of semaphorins, vascular endothelial growth factor, and their common receptor neuropilins and alleic loss of semaphorin locus in epithelial ovarian neoplasms: increased ratio of vascular endothelial growth factor to semaphorin is a poor prognostic factor in ovarian carcinomas. Osada, R., Horiuchi, A., Kikuchi, N., Ohira, S., Ota, M., Katsuyama, Y., Konishi, I. Hum. Pathol. (2006) [Pubmed]
  5. Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype. Bielenberg, D.R., Hida, Y., Shimizu, A., Kaipainen, A., Kreuter, M., Kim, C.C., Klagsbrun, M. J. Clin. Invest. (2004) [Pubmed]
  6. Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B. Tomizawa, Y., Sekido, Y., Kondo, M., Gao, B., Yokota, J., Roche, J., Drabkin, H., Lerman, M.I., Gazdar, A.F., Minna, J.D. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  7. Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns. Sekido, Y., Bader, S., Latif, F., Chen, J.Y., Duh, F.M., Wei, M.H., Albanesi, J.P., Lee, C.C., Lerman, M.I., Minna, J.D. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  8. Semaphorin SEMA3F and VEGF have opposing effects on cell attachment and spreading. Nasarre, P., Constantin, B., Rouhaud, L., Harnois, T., Raymond, G., Drabkin, H.A., Bourmeyster, N., Roche, J. Neoplasia (2003) [Pubmed]
  9. Semaphorin 3F gene from human 3p21.3 suppresses tumor formation in nude mice. Xiang, R., Davalos, A.R., Hensel, C.H., Zhou, X.J., Tse, C., Naylor, S.L. Cancer Res. (2002) [Pubmed]
  10. Semaphorin SEMA3F localization in malignant human lung and cell lines: A suggested role in cell adhesion and cell migration. Brambilla, E., Constantin, B., Drabkin, H., Roche, J. Am. J. Pathol. (2000) [Pubmed]
  11. Promoter characterization of Semaphorin SEMA3F, a tumor suppressor gene. Kusy, S., Potiron, V., Zeng, C., Franklin, W., Brambilla, E., Minna, J., Drabkin, H.A., Roche, J. Biochim. Biophys. Acta (2005) [Pubmed]
  12. Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity. Giger, R.J., Urquhart, E.R., Gillespie, S.K., Levengood, D.V., Ginty, D.D., Kolodkin, A.L. Neuron (1998) [Pubmed]
  13. KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium. Dekker, R.J., Boon, R.A., Rondaij, M.G., Kragt, A., Volger, O.L., Elderkamp, Y.W., Meijers, J.C., Voorberg, J., Pannekoek, H., Horrevoets, A.J. Blood (2006) [Pubmed]
  14. Expression of VEGF, semaphorin SEMA3F, and their common receptors neuropilins NP1 and NP2 in preinvasive bronchial lesions, lung tumours, and cell lines. Lantuéjoul, S., Constantin, B., Drabkin, H., Brambilla, C., Roche, J., Brambilla, E. J. Pathol. (2003) [Pubmed]
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