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Gene Review

Nrp2  -  neuropilin 2

Mus musculus

Synonyms: 1110048P06Rik, NP-2, NP2, Neuropilin-2, Np-2, ...
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Disease relevance of Nrp2

  • Npn-2 is required for the organization and fasciculation of several cranial nerves and spinal nerves [1].
  • We also found that Sema3G binds Neuropilin-2, but not Neuropilin-1, and induces the repulsion of sympathetic axons, but not dorsal root ganglion axons, indicating that Sema3G utilizes Neuropilin-2 as a receptor to repel specific types of axons [2].
  • The whole-animal distribution of 90Y-labeled anti-carcinoembryonic antigen monoclonal antibody NP-2 was evaluated by WBAR in nude mice bearing s.c. implants of GW-39 colon cancer and revealed antitumor uptake specifically as well as significant accumulation of 90Y in the bones [3].

High impact information on Nrp2

  • Thus, Sema3A-Npn-1 and Sema3F-Npn-2 signaling control distinct steps of motor axon growth and guidance during the formation of spinal motor connections [4].
  • In contrast, Sema3F-Npn-2 signaling guides the axons of a medial subset of LMC neurons to the ventral limb, but plays no major role in regulating their fasciculation [4].
  • NrCAM, an immunoglobulin superfamily adhesion molecule of the L1 subfamily, associates with neuropilin-2 and is a component of a receptor complex for Sema3B and Sema3F [5].
  • Thus, Npn-2 and candidate pheromone receptors play distinct and complementary roles in promoting the wiring and patterning of sensory neurons in the accessory olfactory system [6].
  • Analysis of the vomeronasal nerve in neuropilin-2 (npn-2) mutant mice reveals pathfinding defects at multiple choice points [6].

Biological context of Nrp2


Anatomical context of Nrp2


Associations of Nrp2 with chemical compounds


Other interactions of Nrp2

  • These results suggest that NRPs are early genes in embryonic vessel development and that both NP1 and NP2 are required [13].
  • Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis [13].
  • Neuropilin-2 mutant mice exhibit profound and distinct effects on target innervation within the olfactory bulb [14].

Analytical, diagnostic and therapeutic context of Nrp2


  1. Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins. Giger, R.J., Cloutier, J.F., Sahay, A., Prinjha, R.K., Levengood, D.V., Moore, S.E., Pickering, S., Simmons, D., Rastan, S., Walsh, F.S., Kolodkin, A.L., Ginty, D.D., Geppert, M. Neuron (2000) [Pubmed]
  2. Identification and characterization of a novel member of murine semaphorin family. Taniguchi, M., Masuda, T., Fukaya, M., Kataoka, H., Mishina, M., Yaginuma, H., Watanabe, M., Shimizu, T. Genes Cells (2005) [Pubmed]
  3. Use of whole-body autoradiography in cancer targeting with radiolabeled antibodies. Fand, I., Sharkey, R.M., Goldenberg, D.M. Cancer Res. (1990) [Pubmed]
  4. Distinct roles for secreted semaphorin signaling in spinal motor axon guidance. Huber, A.B., Kania, A., Tran, T.S., Gu, C., De Marco Garcia, N., Lieberam, I., Johnson, D., Jessell, T.M., Ginty, D.D., Kolodkin, A.L. Neuron (2005) [Pubmed]
  5. Dual functional activity of semaphorin 3B is required for positioning the anterior commissure. Falk, J., Julien, F., Bechara, A., Fiore, R., Nawabi, H., Zhou, H., Hoyo-Becerra, C., Bozon, M., Rougon, G., Grumet, M., Püschel, A.W., Sanes, J.R., Castellani, V. Neuron (2005) [Pubmed]
  6. Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons. Cloutier, J.F., Giger, R.J., Koentges, G., Dulac, C., Kolodkin, A.L., Ginty, D.D. Neuron (2002) [Pubmed]
  7. Deficiency of neuropilin 2 suppresses VEGF-induced retinal neovascularization. Shen, J., Samul, R., Zimmer, J., Liu, H., Liang, X., Hackett, S., Campochiaro, P.A. Mol. Med. (2004) [Pubmed]
  8. Diverse gene expression and function of semaphorins in developing lung: positive and negative regulatory roles of semaphorins in lung branching morphogenesis. Kagoshima, M., Ito, T. Genes Cells (2001) [Pubmed]
  9. Abnormal lymphatic vessel development in neuropilin 2 mutant mice. Yuan, L., Moyon, D., Pardanaud, L., Bréant, C., Karkkainen, M.J., Alitalo, K., Eichmann, A. Development (2002) [Pubmed]
  10. Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections. Chen, H., Bagri, A., Zupicich, J.A., Zou, Y., Stoeckli, E., Pleasure, S.J., Lowenstein, D.H., Skarnes, W.C., Chédotal, A., Tessier-Lavigne, M. Neuron (2000) [Pubmed]
  11. Guidance of trunk neural crest migration requires neuropilin 2/semaphorin 3F signaling. Gammill, L.S., Gonzalez, C., Gu, C., Bronner-Fraser, M. Development (2006) [Pubmed]
  12. Evidence for gradients of gene expression correlating with zonal topography of the olfactory sensory map. Norlin, E.M., Alenius, M., Gussing, F., Hägglund, M., Vedin, V., Bohm, S. Mol. Cell. Neurosci. (2001) [Pubmed]
  13. Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis. Takashima, S., Kitakaze, M., Asakura, M., Asanuma, H., Sanada, S., Tashiro, F., Niwa, H., Miyazaki Ji, J., Hirota, S., Kitamura, Y., Kitsukawa, T., Fujisawa, H., Klagsbrun, M., Hori, M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  14. Aberrant sensory innervation of the olfactory bulb in neuropilin-2 mutant mice. Walz, A., Rodriguez, I., Mombaerts, P. J. Neurosci. (2002) [Pubmed]
  15. Ontogeny of semaphorins 3A and 3F and their receptors neuropilins 1 and 2 in the kidney. Villegas, G., Tufro, A. Gene Expr. Patterns (2002) [Pubmed]
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