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Gene Review

Serpinb8  -  serine (or cysteine) peptidase inhibitor,...

Mus musculus

Synonyms: CAP-2, CAP2, NK10, Serpin B8, Spi8, ...
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Disease relevance of Serpinb8

  • Chlorpromazine-induced hypothermia did not influence the antitumor effect of CAP-2 [1].
  • The antileukemic combined effect of reserpine with 1-gamma-chloropropyl-2-chloromethylpiperidine hydrobromide (CAP-2) and other antitumor agents was studied on mouse leukemia L1210 in comparison with the effects of other Rauwolfia alkaloids and sympatholytic drugs [1].

High impact information on Serpinb8

  • These mAbs inhibit phosphorylation of CAP2 by endogenous CCV casein kinase II [2].
  • Monoclonal antibodies C-10B2 and C-4E5 immunoprecipitate clathrin-coated vesicles (CCVs) and react with CAP2 epitopes accessible to chymotrypsin on the vesicle [2].
  • We report here the cloning of 3 new CAP isoforms, CAP2, CAP3, and CAP4, from mouse adipose tissue [3].
  • The improved program (CAP2) assembled each of seven data sets, six of which contain repetitive sequences of very strong similarity, into a single sequence [4].
  • The influence of two antidepressants, iproniazid and imipramine, was examined on the antileukemic combination effect of reserpine with 1-gamma-chloropropyl-2-chloromethylpiperidine hydrobromide (CAP-2), mitomycin C, or vinblastine on L1210 [5].

Biological context of Serpinb8

  • It may be concluded that the antileukemic synergism depends partially on the interaction between reserpine and CAP-2 or other antitumor agents in relation to body temperature and/or action on the central nervous system in leukemic mice [1].

Anatomical context of Serpinb8


  1. Comination effect of reserpine with antitumor agents in L1210. Miyamoto, K., Wakusawa, S., Koshura, R. Gann = Gan. (1980) [Pubmed]
  2. Mapping two functional domains of clathrin light chains with monoclonal antibodies. Kohtz, D.S., Georgieva-Hanson, V., Kohtz, J.D., Schook, W.J., Puszkin, S. J. Cell Biol. (1987) [Pubmed]
  3. Cloning and characterization of Cbl-associated protein splicing isoforms. Zhang, M., Kimura, A., Saltiel, A.R. Mol. Med. (2003) [Pubmed]
  4. An improved sequence assembly program. Huang, X. Genomics (1996) [Pubmed]
  5. Influence of iproniazid on the combination effect of reserpine with antitumor agents on l1210. Wakusawa, S., Miyamoto, K., Koshiura, R. Gann = Gan. (1982) [Pubmed]
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