The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt
  • Ensembl

Table of contents

About

Terms

 

Gene Review: 

Serpinb8  -  serine (or cysteine) peptidase inhibitor,...

Mus musculus

Synonyms: CAP-2, CAP2, NK10, Serpin B8, Spi8, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Serpinb8

  • Chlorpromazine-induced hypothermia did not influence the antitumor effect of CAP-2 [1].
  • The antileukemic combined effect of reserpine with 1-gamma-chloropropyl-2-chloromethylpiperidine hydrobromide (CAP-2) and other antitumor agents was studied on mouse leukemia L1210 in comparison with the effects of other Rauwolfia alkaloids and sympatholytic drugs [1].
 

High impact information on Serpinb8

  • These mAbs inhibit phosphorylation of CAP2 by endogenous CCV casein kinase II [2].
  • Monoclonal antibodies C-10B2 and C-4E5 immunoprecipitate clathrin-coated vesicles (CCVs) and react with CAP2 epitopes accessible to chymotrypsin on the vesicle [2].
  • We report here the cloning of 3 new CAP isoforms, CAP2, CAP3, and CAP4, from mouse adipose tissue [3].
  • The improved program (CAP2) assembled each of seven data sets, six of which contain repetitive sequences of very strong similarity, into a single sequence [4].
  • The influence of two antidepressants, iproniazid and imipramine, was examined on the antileukemic combination effect of reserpine with 1-gamma-chloropropyl-2-chloromethylpiperidine hydrobromide (CAP-2), mitomycin C, or vinblastine on L1210 [5].
 

Biological context of Serpinb8

  • It may be concluded that the antileukemic synergism depends partially on the interaction between reserpine and CAP-2 or other antitumor agents in relation to body temperature and/or action on the central nervous system in leukemic mice [1].
 

Anatomical context of Serpinb8

References

  1. Comination effect of reserpine with antitumor agents in L1210. Miyamoto, K., Wakusawa, S., Koshura, R. Gann = Gan. (1980) [Pubmed]
  2. Mapping two functional domains of clathrin light chains with monoclonal antibodies. Kohtz, D.S., Georgieva-Hanson, V., Kohtz, J.D., Schook, W.J., Puszkin, S. J. Cell Biol. (1987) [Pubmed]
  3. Cloning and characterization of Cbl-associated protein splicing isoforms. Zhang, M., Kimura, A., Saltiel, A.R. Mol. Med. (2003) [Pubmed]
  4. An improved sequence assembly program. Huang, X. Genomics (1996) [Pubmed]
  5. Influence of iproniazid on the combination effect of reserpine with antitumor agents on l1210. Wakusawa, S., Miyamoto, K., Koshiura, R. Gann = Gan. (1982) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities