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Stam  -  signal transducing adaptor molecule (SH3...

Mus musculus

Synonyms: STAM-1, STAM1, Signal transducing adapter molecule 1, Stam1
 
 
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High impact information on Stam

  • We previously reported that the STAM family members STAM1 and STAM2 are phosphorylated on tyrosine upon stimulation with cytokines through the gammac-Jak3 signaling pathway, which is essential for T-cell development [1].
  • These STAM1(-/-) STAM2(-/-) mice showed a significant reduction in thymocytes and a profound reduction in peripheral mature T cells [1].
  • Furthermore, we observed that primary hippocampal neurons derived from STAM1(-/-) mice are vulnerable to cell death induced by excitotoxic amino acids or an NO donor [2].
  • Here we generated mice lacking STAM1 by using homologous recombination with embryonic stem cells [2].
  • These data suggest that STAM1 is dispensable for cytokine-mediated signaling in lymphocytes but may be involved in the survival of hippocampal CA3 pyramidal neurons [2].
 

Biological context of Stam

 

Anatomical context of Stam

  • Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival [1].
 

Other interactions of Stam

  • Here we show that STAM1 and STAM2 are localized to the endosomal membrane [4].

References

  1. Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival. Yamada, M., Ishii, N., Asao, H., Murata, K., Kanazawa, C., Sasaki, H., Sugamura, K. Mol. Cell. Biol. (2002) [Pubmed]
  2. Loss of hippocampal CA3 pyramidal neurons in mice lacking STAM1. Yamada, M., Takeshita, T., Miura, S., Murata, K., Kimura, Y., Ishii, N., Nose, M., Sakagami, H., Kondo, H., Tashiro, F., Miyazaki, J.I., Sasaki, H., Sugamura, K. Mol. Cell. Biol. (2001) [Pubmed]
  3. Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice. Ishii, N., Owada, Y., Yamada, M., Miura, S., Murata, K., Asao, H., Kondo, H., Sugamura, K. Mol. Cell. Biol. (2001) [Pubmed]
  4. Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation. Kanazawa, C., Morita, E., Yamada, M., Ishii, N., Miura, S., Asao, H., Yoshimori, T., Sugamura, K. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
 
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