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Stam2  -  signal transducing adaptor molecule (SH3...

Mus musculus

Synonyms: 1200004O12Rik, 5730456G07Rik, BB145015, Hbp, Hrs-binding protein, ...
 
 
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High impact information on Stam2

  • We previously reported that the STAM family members STAM1 and STAM2 are phosphorylated on tyrosine upon stimulation with cytokines through the gammac-Jak3 signaling pathway, which is essential for T-cell development [1].
  • These STAM1(-/-) STAM2(-/-) mice showed a significant reduction in thymocytes and a profound reduction in peripheral mature T cells [1].
  • A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP [2].
  • Association of Hbp with a binding partner(s) via the SH3 domain seems to be essential for Hbp to exert its function [2].
  • In this study, we searched for Hbp-binding proteins by a far Western screening and isolated a mouse cDNA clone encoding a deubiquitinating enzyme mUBPY as an Hbp SH3-binding protein. mUBPY has two Hbp-SH3 domain binding sites [2].
 

Biological context of Stam2

  • Deletion mutants of Hbp lacking either the SH3 domain or the Hrs binding domain showed dominantly negative effects on the intracellular degradation of a growth factor and its receptor, but not on the internalization of growth factor/receptor complexes [3].
  • The tissue distribution of different Stam2 mRNA variants was determined by reverse transcription-polymerase chain reaction, and the consequences of the alternative splicing at the protein level were analyzed by western blot with the polyclonal anti-STAM2 antibody [4].
  • Involvement of hrs binding protein in IgE receptor-triggered exocytosis in RBL-2H3 mast cells [5].
 

Anatomical context of Stam2

  • CONCLUSIONS: Hbp is thought to be closely associated with Hrs on early endosomes [3].
  • Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival [1].
 

Physical interactions of Stam2

  • Hbp was co-immunoprecipitated with Hrs, and its intracellular localization was similar to that of Hrs [3].
 

Other interactions of Stam2

  • Here we show that STAM1 and STAM2 are localized to the endosomal membrane [6].
  • A hrs binding protein having a Src homology 3 domain is involved in intracellular degradation of growth factors and their receptors [3].

References

  1. Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival. Yamada, M., Ishii, N., Asao, H., Murata, K., Kanazawa, C., Sasaki, H., Sugamura, K. Mol. Cell. Biol. (2002) [Pubmed]
  2. A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP. Kato, M., Miyazawa, K., Kitamura, N. J. Biol. Chem. (2000) [Pubmed]
  3. A hrs binding protein having a Src homology 3 domain is involved in intracellular degradation of growth factors and their receptors. Takata, H., Kato, M., Denda, K., Kitamura, N. Genes Cells (2000) [Pubmed]
  4. Splice variant of mouse Stam2 mRNA in nervous and muscle tissue contains additional exon with stop codon within region coding for VHS domain. Curlin, M., Lucić, V., Gajović, S. Croat. Med. J. (2006) [Pubmed]
  5. Involvement of hrs binding protein in IgE receptor-triggered exocytosis in RBL-2H3 mast cells. Murai, S., Kitamura, N. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  6. Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation. Kanazawa, C., Morita, E., Yamada, M., Ishii, N., Miura, S., Asao, H., Yoshimori, T., Sugamura, K. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
 
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